research Hydrochlorothiazide/Indometacin: Lupus Erythematosus in a 73-Year-Old Woman After Hydroxycarbamide Treatment for Essential Thrombocythemia
A woman developed lupus after taking hydroxyurea for two years.
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450-480 / 1000+ results research Scalp Dermatology for the Hair Restoration Surgeon
Hair restoration surgeons need scalp dermatology knowledge to improve patient outcomes.
research Mono-Letter Mnemonics in Dermatology
Mnemonics with one letter are useful and easy to remember for learning dermatology.
research Lichen Sclerosus Et Atrophicus and Kraurosis Vulvae
Lichen sclerosus et atrophicus is generally not considered precancerous, but there are exceptions.
research Epithelial Barrier Function: Assembly and Structural Features of the Cornified Cell Envelope
The cornified cell envelope forms a protective barrier in skin and hair, using specific proteins and lipids to maintain effectiveness.
research Mucocutaneous Reactions to Chemotherapy
Chemotherapy can cause various skin reactions, with hair loss being the most common, and proper diagnosis and treatment of these reactions are important.
research Adverse Effects Associated with Long-Term Administration of Azole Antifungal Agents
Long-term use of azole antifungals can cause hair loss, hormonal imbalances, and severe skin reactions.
research Developing Stratified Epithelia: Lessons from the Epidermis and Thymus
The skin and thymus develop similarly to protect and support immunity.
research Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus
The conclusion is that Pigmented Epithelioid Melanocytoma can start from hair follicle stem cells or from a mole on the skin.
research Histology, Lectin Histochemistry, and Ultrastructure of Interdigital Gland in Crossbred Sheep
The interdigital gland in crossbred sheep is similar to skin and has specialized structures for secretion.
research Characteristics of KRT80 and Its Roles in Neoplastic Diseases
KRT80 may worsen cancer by increasing growth and spread, but its full effects on treatment and outcomes need more research.
research Study of Clinical Spectrum of Geriatric Dermatoses in Patients Attending a Multi-Specialty Hospital
Older adults most often had skin infections and eczema at a hospital in Nepal.
research The Association of Diffuse Alopecia Areata and Psoriasis Vulgaris in a Young Child
A young child with alopecia areata and psoriasis improved with treatment, suggesting a link between the two conditions.
research LSD1 Is Critical for Epidermal Development and Skin Barrier Formation
LSD1 is essential for healthy skin development and creating the skin's protective barrier.
research Unexpected Expression of Hemoglobin Alpha as an Endogenous Antioxidant in Epidermal Keratinocytes
Hemoglobin α acts as an antioxidant in skin cells, especially protecting hair follicle stem cells from UV damage.
research Roles of the Hedgehog Signaling Pathway in Cutaneous Physiology and Oncology
The Hedgehog Signaling Pathway is important for skin and hair development and skin cancer treatment, but more research is needed to understand it fully.
research Methotrexate, Tacrolimus, Voriconazole: High-Risk Cutaneous Squamous Cell Carcinoma in a 65-Year-Old Man
A 65-year-old man developed a serious skin cancer linked to a drug he was taking for a fungal infection after a bone marrow transplant.
research Highlights
Acne is not a key diagnostic feature for PCOS, postadolescent men with acne may have insulin resistance, melanoma patients often have few moles, tumor size in CSCC indicates higher risk of serious outcomes, and hidradenitis suppurativa is linked to higher risk of heart problems and death.
research Editors' Picks
Collagen VII helps skin heal and stay strong, sirolimus may lower skin cancer risk in kidney transplant patients, high-molecular-mass hyaluronan helps naked mole rats resist cancer, dermal γδ T cells aid in hair growth in rodents, and overexpression of IL-33 in mouse skin causes itchiness, offering a model for studying allergic inflammation treatments.
research Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein
Skin cells and certain hair follicle areas produce hemoglobin, which may help protect against oxidative stress like UV damage.
research Keratin 17 in Disease Pathogenesis: From Cancer to Dermatoses
Keratin 17 is linked to various diseases, including cancer and skin conditions, and may be a target for diagnosis and treatment.
research Cervical Cancer Metastasis to the Scalp Presenting as Alopecia Neoplastica
A woman with cervical cancer had rare scalp metastasis causing a unique type of hair loss.
research Cetuximab-Induced Hypertrichosis of the Scalp and Eyelashes
A cancer drug caused unusual hair growth on a 100-year-old man's scalp and eyelashes.
research Eccrine Duct Dilation as a Marker of Cicatricial Alopecia
Enlarged sweat gland ducts may indicate scarring hair loss.
research Models for Skin Cancer
The document discussed the three most common types of skin cancer: malignant melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). Malignant melanoma, originating from melanocytes, was noted as the most lethal. BCC, the most common cancer, was debated to potentially arise from hair follicle keratinocytes and was associated with mutations in the sonic hedgehog (SHH) pathway, suggesting a link to failed organogenesis. SCC, also arising from keratinocytes, was described as more aggressive than BCC, with the potential to form lethal metastases, unlike BCC, which rarely metastasizes. The document also covered the use of in vivo and in vitro models for studying these skin cancers.
research Iron, Copper, and Magnesium Concentration in Hair and Risk of Esophageal Cancer: A Nested Case-Control Study
Higher iron levels in hair may increase the risk of esophageal cancer.
research Mutational Landscape of Extramammary Paget Disease
The document concludes that ERBB2 mutations are common in extramammary Paget disease and may respond to systemic treatments like cancer immunotherapy.
research Developing Optical Biometrics Using Optical Coherence Tomography for Medical Screening and Diagnosis
OCT can effectively screen and diagnose various medical conditions non-invasively.
research The Metabolism of Testosterone by Dermal Papilla Cells Cultured from Scalp Follicles of Men with Androgenetic Alopecia
Testosterone metabolism in balding scalp cells may not be the main cause of hair loss.
research Integrin Signaling Regulates YAP/TAZ to Control Skin Homeostasis
The study demonstrated that YAP and TAZ proteins were crucial for skin homeostasis, particularly in the basal layer of the skin, where they were found in the nucleus and increased during wound healing. Deleting YAP and TAZ in the skin of adult mice resulted in slower cell proliferation, hair loss, and impaired wound regeneration. The nuclear localization of YAP/TAZ was regulated by Integrin-Src signaling, which was influenced by contact with the basal extracellular matrix. This mechanism was also observed in other squamous epithelia and squamous cell carcinomas. In contrast, columnar epithelia used a different mechanism involving Hippo signaling to keep YAP/TAZ in the cytoplasm. However, when columnar epithelial tumors lost their apical domain, YAP/TAZ became nuclear, making the tumors sensitive to the Src inhibitor Dasatinib.