Hydrochlorothiazide/Indometacin: Lupus Erythematosus in a 73-Year-Old Woman After Hydroxycarbamide Treatment for Essential Thrombocythemia

    October 2009 in “ Reactions Weekly ”
    NULL AUTHOR_ID
    Image of study
    TLDR A woman developed lupus after taking hydroxyurea for two years.
    A 73-year-old woman developed lupus erythematosus after two years of treatment with hydroxycarbamide (hydroxyurea) for essential thrombocythemia. She presented with facial erythema, labial erosions, erythematous and pigmented facial plaques, squamous cheilitis, multiple erosions on her upper lip, and telogen effluvium. Histology and direct immunofluorescence confirmed the diagnosis, and laboratory tests showed inflammatory anaemia, a high ANA titre of 1:3200, and positive anticardiolipin antibodies. Upon discontinuing hydroxycarbamide, her symptoms improved within one week. The pharmacovigilance enquiry suggested a probable link between hydroxyurea and the induction of lupus.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 404 results

    Similar Research

    5 / 1000+ results
      Drug-Induced Changes in Hair Growth

      research Drug-Induced Changes in Hair Growth

      August 1994 in “Drugs & Therapy Perspectives”
      Some drugs can cause hair loss or growth, but hair usually returns to normal after stopping the drug.
      Drug-Induced Hair Loss and Hair Growth

      research Drug-Induced Hair Loss and Hair Growth

      147 citations, April 1994 in “Drug Safety”
      Some drugs can cause hair loss or increase hair growth, but these effects are usually reversible when the drug is stopped.
      Cutaneous Drug Reaction Case Reports

      research Cutaneous Drug Reaction Case Reports

      January 2003 in “American Journal of Clinical Dermatology”
      Various drugs caused different skin reactions, including allergic and inflammatory responses.
      Psoriasis

      research Psoriasis

      August 1994 in “Drugs & Therapy Perspectives”
      Psoriasis treatments range from topical creams to systemic medications with serious side effects, and while treatments can manage symptoms, there is no cure.