Lichen Sclerosus Et Atrophicus and Kraurosis Vulvae

September 1961 in “ Archives of Dermatology ”

William M. George

lichen sclerosus et atrophicus squamous cell carcinoma colchicine anagen hair loss catagen phase telogen phase telogen effluvium

TLDR Lichen sclerosus et atrophicus is generally not considered precancerous, but there are exceptions.

Dr. Richard A. Oberfield's article in the May 1961 issue of the Archives of Dermatology asserts that lichen sclerosus et atrophicus is not a precancerous lesion, as none of the studied patients, including five males with penile involvement, developed carcinoma. However, Dr. William M. George presents a counterexample of a man with lichen sclerosus et atrophicus who developed squamous cell carcinoma in situ in the affected penile area. Additionally, Dr. Frederick D. Malkinson addresses a misinterpretation by A. Kligman regarding his research on colchicine-induced hair loss, clarifying that colchicine induces anagen hair loss and proposing that colchicine may cause rapid hair loss by inducing catagen and subsequent telogen phases, rather than directly causing telogen effluvium.

View this study on doi.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 88 results

community Is hair thinning or loss associated with pain?

in Research/Science 6 upvotes 2 years ago

Hair thinning/loss associated with burning scalp pain. Finasteride helped relieve "DHT itch" for one person.

community I've tried everything and my hair is still thinning

in Chat 6 upvotes 2 years ago

The user has tried finasteride, oral minoxidil, iron supplements, vitamin D, and vitamin B12, but their hair is still thinning after 5 years. Another user suggested trying dutasteride.

community I’m 14 years old and I’m losing more hair than my dad. I’ve gone to the doctor 2 times because of this and I’ve received no help. I’m starting to feel like It’s worthless and my hairs gonna look like this forever. I don’t know how anyone could help me but it’s always worth a shot.

in Treatment 5 years ago

A 14 year old who is experiencing hair loss and has not received any help from the doctor, with advice being given to try different doctors, get tested for underlying conditions and intolerances, buzz it short as an option and treatments that could slow down or reverse the hair loss such as minoxidil, finasteride, RU58841 and addressing the cause of the hair loss.

community Fibrosing alopecia in a pattern distribution

in Research/Science 14 upvotes 1 year ago

A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

community Minoxidil For 2 Years, What is this?

in Treatment 111 upvotes 1 year ago

The user has experienced significant hair thinning despite using 2.5 mg minoxidil for 2 years. Other users suggest adding finasteride or dutasteride and consulting a dermatologist for a proper diagnosis.

community My result with 5month min+micro1m+tretinoin0.0025+nizoral

in Progress Pictures 100 upvotes 2 years ago

The conversation discusses hair loss treatment results after 5 months using Minoxidil, microneedling with a 1mm length every 5 days, Tretinoin (0.0025%), and Nizoral. The user noticed an increase in hair density.