Lichen Sclerosus Et Atrophicus and Kraurosis Vulvae

    September 1961 in “ Archives of Dermatology ”
    William M. George
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    TLDR Lichen sclerosus et atrophicus is generally not considered precancerous, but there are exceptions.
    Dr. Richard A. Oberfield's article in the May 1961 issue of the Archives of Dermatology asserts that lichen sclerosus et atrophicus is not a precancerous lesion, as none of the studied patients, including five males with penile involvement, developed carcinoma. However, Dr. William M. George presents a counterexample of a man with lichen sclerosus et atrophicus who developed squamous cell carcinoma in situ in the affected penile area. Additionally, Dr. Frederick D. Malkinson addresses a misinterpretation by A. Kligman regarding his research on colchicine-induced hair loss, clarifying that colchicine induces anagen hair loss and proposing that colchicine may cause rapid hair loss by inducing catagen and subsequent telogen phases, rather than directly causing telogen effluvium.
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