Iron, Copper, and Magnesium Concentration in Hair and Risk of Esophageal Cancer: A Nested Case-Control Study

December 2023 in “ Archives of iranian medicine ”

Maryam Hashemian, Hossein Poustchi, Maryam Sharafkhah, Akram Pourshams, Fatemeh Mohammadi‐Nasrabadi, Azita Hekmatdoost, Reza Malekzadeh

iron copper magnesium hair samples inductively coupled plasma mass spectrometry ICP-MS

TLDR Higher iron levels in hair may increase the risk of esophageal cancer.

This nested case-control study within the Golestan Cohort Study examined the association between iron, copper, and magnesium concentrations in hair samples and the risk of esophageal squamous cell carcinoma (ESCC). The study included 96 incident ESCC cases and matched cancer-free controls. Using inductively coupled plasma mass spectrometry (ICP-MS), the researchers found that higher iron concentrations in hair were significantly associated with an increased risk of ESCC (OR=1.41, 95% CI=1.03-1.92). However, no significant associations were observed for copper and magnesium concentrations. The findings suggest that higher iron status may be related to a higher risk of ESCC in this population.

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