Models for Skin Cancer

    October 2007 in “ The Cancer Handbook ”
    Michael P. Philpott, Daniele Bergamaschi, Alan Storey
    TLDR Malignant melanoma is the deadliest skin cancer, while BCC is the most common but rarely spreads, and SCC is more aggressive than BCC.
    The document discussed the three most common types of skin cancer: malignant melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). Malignant melanoma was noted as the most lethal, originating from melanocytes. BCC, the most common cancer, was debated to arise from hair follicle keratinocytes and was associated with mutations in the sonic hedgehog (SHH) pathway, suggesting a link to failed organogenesis. SCC, also from keratinocytes, was described as more aggressive than BCC, with the potential for lethal metastases, unlike BCC, which rarely metastasizes. The document explored both in vivo and in vitro models for studying these cancers.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    6 / 10 results

      community Hair Cloning, Trials were supposed to begin 2020-2021

      in Technology  48 upvotes 6 years ago
      The conversation discusses hair cloning trials expected to start in 2020-2021 and mentions concerns about potential delays due to the Coronavirus. Treatments like Minoxidil, finasteride, and RU58841 are referenced.

      community Oral vs Topical Finasteride for Trans Women

      in Transgender 1 year ago
      A user is using a Finoxidil topical spray and is curious if oral Finasteride would be more effective, considering they are already on a DHT blocker called Cyproterone. They are concerned about the potential impact of oral Finasteride on their transition.

      community Expectations control for SCUBE3

      in Research/Science  21 upvotes 2 years ago
      SCUBE3, a protein linked to hair growth in moles, was discovered over 25 years ago and is being developed by Amplifica for potential hair loss treatment. Concerns exist about SCUBE3's association with cancer, as it is a protein that promotes cell growth, which could potentially trigger cancer development if used for hair growth therapy.

      community Why I deleted my YouTube channel Part I

      in Update  118 upvotes 4 years ago
      A YouTuber named Kevin, also known as Rider_Of_Roach, who deleted his YouTube channel due to personal attacks and controversy surrounding his views on hair loss treatments. He advocated for FDA-approved treatments like finasteride and minoxidil but faced backlash from those who disagreed with him. The conversation also discusses his past trolling behavior and a lawsuit he filed against a website that published false information about him. Despite some disagreements, many viewers appreciated his research-based content and hope to see him return in the future.

      community Dermatologist told me to quit fin after turning 40

      in Finasteride/Dutasteride  194 upvotes 2 years ago
      A dermatologist advised a patient to stop taking finasteride (fin) after turning 40 due to potential risk of aggressive prostate cancer. The patient and others in the conversation debated this advice, discussing the relationship between finasteride, prostate cancer, and hair loss, and considering alternatives like topical finasteride.

      community 5% Minoxidil after 4 months - started with twice a day but went down to once because I kept forgetting in the morning. Really happy with how it is going!

      in Progress Pictures  438 upvotes 2 years ago
      The conclusion of the conversation is that the user started using 5% Minoxidil for hair loss and is happy with the progress. They also mentioned being trans and coming off testosterone, which they believe will help prevent further hair loss. Some users suggested using finasteride as well.

    Related Research

    1 / 1 results