55 citations,
January 1988 in “Dermatology” Diphencyprone treatment for alopecia areata can cause vitiligo in some patients.
53 citations,
March 2014 in “Cold Spring Harbor Perspectives in Medicine” The document explains different types of hair loss, their causes, and treatments, and suggests future research areas.
50 citations,
July 1981 in “Archives of Dermatology” DNCB helps regrow hair in alopecia areata patients, but safer alternatives are needed.
47 citations,
April 2000 in “The American journal of pathology” Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.
42 citations,
July 2014 in “Journal of biological chemistry/The Journal of biological chemistry” Heparan sulfate is important for hair growth, preventing new hair formation in mature skin, and controlling oil gland development.
40 citations,
July 2017 in “Frontiers in Medicine” Early and personalized treatment for hair loss in young people is crucial to prevent permanent damage and should include psychological support.
38 citations,
July 1989 in “Archives of dermatological research” Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.
36 citations,
August 2009 in “PubMed” The review suggests seeing a dermatologist for scarring hair loss and using treatments like minoxidil or finasteride for common male and female pattern hair loss.
33 citations,
April 2020 in “Journal of Clinical Investigation” Stress in hair follicle stem cells causes inflammation in a chronic skin condition through a specific immune response pathway.
32 citations,
March 2019 in “Climacteric” Premature ovarian insufficiency (POI) can harm women's sexual health, and they may benefit from hormone therapy and counseling.
30 citations,
June 1993 in “The Journal of Cell Biology” In this study, researchers investigated the effects of a mutant Adenovirus E1a oncoprotein, NTdl646, on keratinocyte growth and differentiation in transgenic mice. The protein was expressed specifically in the skin using a keratin 5 promoter, resulting in two lines of mice with abnormal hair phenotypes, including short, crooked hair shafts and dystrophic or absent inner root sheaths. Despite these hair follicle maturation disturbances, the interfollicular epidermis remained normal, and there was no increase in spontaneous or chemically induced skin tumors. The study concluded that while the transgene disrupted keratinocyte maturation, it did not lead to increased epidermal proliferation or neoplastic growth.
29 citations,
July 2010 in “Journal of Cutaneous Medicine and Surgery” Treatments for Frontal Fibrosing Alopecia have not been proven effective.
27 citations,
January 2020 in “Experimental Dermatology” Immune cells affect hair growth and could lead to new hair loss treatments.
23 citations,
July 2003 in “Pharmacology, Biochemistry and Behavior” Finasteride blocks progesterone's effect on absence seizures in rats.
20 citations,
January 2017 in “Epilepsia” Blocking neurosteroid production can lead to more seizures and faster epilepsy onset in rats.
20 citations,
June 1964 in “Archives of Dermatology” Systemic corticosteroids may effectively treat follicular mucinosis.
18 citations,
July 2022 in “Chemistry - an Asian journal” Scientists created a 3D printed skin that includes hair and layers similar to real skin using a special gel.
18 citations,
March 2016 in “Journal of Investigative Dermatology” Vitamin D and calcium are essential for normal hair growth.
18 citations,
August 2011 in “Medical Hypotheses” Physical inactivity is a primary cause of many human illnesses.
16 citations,
February 2022 in “Science Advances” Follistatin and LIN28B together improve the ability of inner ear cells in mice to regenerate into hearing cells.
16 citations,
November 2016 in “Journal of Cosmetic and Laser Therapy” Laser and light therapies, especially the 308 nm excimer laser, are effective and safe for treating alopecia areata, but more research is needed.
16 citations,
January 2015 in “Current problems in dermatology” Alopecia Areata is an autoimmune hair loss condition that needs more research for better treatments.
16 citations,
April 2011 in “Recent Patents on Inflammation & Allergy Drug Discovery” Alopecia Areata is an autoimmune disease causing hair loss in patches, often starting before age 20, and while some cases recover on their own, treatments include topical corticosteroids, minoxidil, and promising new methods like IL-31 antibodies and 308-nm Excimer laser therapy.
12 citations,
July 2016 in “British journal of dermatology/British journal of dermatology, Supplement” Different hair fiber development might explain why hair loss severity varies in patients with a specific genetic mutation, and treatments that thicken hair could help.
12 citations,
June 2009 in “Journal of Cosmetic Dermatology” Loose Anagen Hair syndrome occurs in dark-skinned children and often improves on its own.
11 citations,
January 1985 in “British Journal of Dermatology” The document concludes that an inherited nail condition often improves on its own, and spironolactone effectively treats acne in women.
10 citations,
March 2014 in “International Journal of Dermatology” A hand-held dermatoscope helped differentiate between pressure-induced alopecia and alopecia areata in a young patient, who then experienced hair regrowth within a month.
10 citations,
January 2008 in “Acta dermato-venereologica” Carbamazepine caused hair loss and skin eruptions in a woman, which improved after stopping the medication.
9 citations,
August 2021 in “International journal of molecular sciences” PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.
8 citations,
September 2021 in “Journal of Cosmetic Dermatology” Some diets and supplements might help with skin disorders, but their effectiveness varies and more research is needed.