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research High-performance liquid chromatography–diode array and electrospray-mass spectrometry analysis of non-allowed substances in cosmetic products for preventing hair loss and other hormone-dependent skin diseases
This study developed a new HPLC method for detecting prohibited substances like minoxidil and hydrocortisone in cosmetic products, achieving high sensitivity and successful application to real-world samples.
research C2orf37 mutational spectrum in Woodhouse–Sakati syndrome patients
This study identified four novel mutations in the C2orf37 gene among Woodhouse–Sakati syndrome patients, doubling known mutations, and found no significant link between isolated symptoms like deafness and dystonia and these mutations.
research Prevalence of Common Skin Diseases and Their Associated Factors among Military Personnel in Korea: A Cross-sectional Study
This study found a high prevalence of skin diseases, such as acne and tinea pedis, among Korean military personnel, highlighting their potential impact on soldiers' daily lives.
research Phytochemical analyses of Ziziphus jujuba Mill. var. spinosa seed by ultrahigh performance liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry
This study identified the main secondary metabolites in Ziziphus jujuba seeds and confirmed that UPLC-MS/MS and GC-MS effectively demonstrate their pharmaceutical quality.
research (Un)targeted Scanning of Locks of Hair for Drugs of Abuse by Direct Analysis in Real Time–High-Resolution Mass Spectrometry
This study reports that a new DART-HRMS method can effectively analyze intact hair for drug use timelines, with cocaine detection aligning with forensic standards and identifying multiple drugs from high-resolution data.
research MALDI (matrix assisted laser desorption ionization) Imaging Mass Spectrometry (IMS) of skin: Aspects of sample preparation
This review discusses the critical parameters for MALDI IMS sample preparation in skin analysis and highlights its applications in wound healing, neoplasia, and infection research, but reports no new clinical results.
research Gas chromatography/mass spectrometry based hair steroid profiling may reveal pathogenesis in hair follicles of the scalp
This study found that using hair steroid profiling, dutasteride treatment led to reduced dihydrotestosterone levels and DHT/testosterone ratio in patients with male-pattern baldness.
research Expanding the Phenotypic Spectrum of Olmsted Syndrome
This study found that mutations in the TRPV3 gene can cause a broader range of symptoms in Olmsted syndrome than previously recognized, including severe palmoplantar keratoderma without other classic features.
research Revisiting hyper- and hypo-androgenism by tandem mass spectrometry
The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.
research Dyeing regions of oxidative hair dyes in human hair investigated by nanoscale secondary ion mass spectrometry
This study found that melanin granules in black human hair are key dyeing regions for oxidative hair coloring, as confirmed by nanoscale mass spectrometry analysis detecting deuterium ions.
research Discrimination between basal cell carcinoma and hair follicles in skin tissue sections by Raman micro-spectroscopy
This preliminary study suggests that Raman micro-spectroscopy can help differentiate basal cell carcinoma from hair follicles in skin tissue sections, although some misclassification of hair follicles as carcinoma was observed.
research The Phenotypic and Genotypic Spectra of Ichthyosis With Confetti Plus Novel Genetic Variation in the 3′ End ofKRT10
This study identified major criteria including ectodermal malformations for diagnosing ichthyosis with confetti, and revealed significant genetic variation in the disease locus within the general population.
research PTCH1 Germline Mutations and the Basaloid Follicular Hamartoma Values in the Tumor Spectrum of Basal Cell Carcinoma Syndrome (NBCCS)
This study suggests that NBCCS and BFHS may be the same genetic condition, which could help improve identification and management of misdiagnosed cases with specific surveillance strategies.
research Investigation by Imaging Mass Spectrometry of Biomarker Candidates for Aging in the Hair Cortex
In this study, researchers identified three molecules in hair that varied with age, suggesting potential markers for aging and targets for cosmetic products.
research Simultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometry
This study developed a novel method to simultaneously measure finasteride, dutasteride, and related biomarkers in serum, finding that both drugs lowered DHT levels while increasing substrate concentrations.
research Synthesis of 5,6,6-[2H3]finasteride and quantitative determination of finasteride in human plasma at picogram level by an isotope-dilution mass spectrometric method
Accurate method measures finasteride levels in human plasma using gas chromatography-mass spectrometry.
research Expansion of the spectrum of ITGB6-related disorders to adolescent alopecia, dentogingival abnormalities and intellectual disability
This study found that a novel rare variant in ITGB6 may cause intellectual disability, alopecia, and dentogingival anomalies in a specific Pakistani family, highlighting a potential role for ITGB6 beyond enamel formation.
research Defining hyperandrogenaemia according to the free androgen index in Chinese women: a cross-sectional study
This study established a normative free androgen index range of 0.7-6.4 and identified a cut-off value of 6.1 for reproductive-age women in southern China, highlighting hyperandrogenic women's increased metabolic disorder risks.
research Integrated flow injection-solid phase spectrophotometric determination of minoxidil
New method measures minoxidil concentration faster, more accurately, and automatically.
research Gas Chromatography Tandem Mass Spectrometry for Biomarkers of Alcohol Abuse in Human Hair
This study developed a faster method to analyze fatty acid ethyl esters in human hair, potentially distinguishing alcohol consumption levels more efficiently.
research Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry
This study identified previously unknown phase I and phase II metabolites of finasteride in human bile and urine using a specialized bile collection technique and advanced mass spectrometry analysis.
research Studies on the persistence of estradiol benzoate and nortestosterone decanoate in hair of cattle following treatment with growth promoters, determined by ultra-high-performance liquid chromatography–tandem mass spectrometry
Detecting steroid esters in cattle hair is inconsistent and influenced by sampling factors.
research Metabolic study of androsta-1,4,6-triene-3,17-dione in horses using liquid chromatography/high resolution mass spectrometry
This study concluded that the best approach for detecting Androsta-1,4,6-triene-3,17-dione administration in horses is monitoring the metabolites M1b or M4 in urine, detectable up to 77 hours post-administration.
research Development of a new gas chromatography–mass spectrometry (GC–MS) methodology for the evaluation of 5α-reductase activity
A new method was developed to accurately measure enzyme activity related to prostate health.
research Cutaneous reactions to targeted therapies in children with CNS tumors: A cross‐sectional study
In this study, 96% of children with CNS tumors receiving MAPK and mTOR inhibitors experienced common, treatable skin reactions, occasionally requiring therapy adjustments.
research Study on dissolution mechanism of cortisol and cortisone from hair matrix with liquid chromatography–tandem mass spectrometry
Cortisol and cortisone release from hair increases in steps over time during incubation.
research A liquid chromatography/tandem mass spectrometry method for determination of aristolochic acid‐I in rat plasma
This study developed and validated a sensitive liquid chromatography–mass spectrometry method to measure aristolochic acid‐I in rat plasma, successfully applying it to pharmacokinetic research.
research A rapid, simple, specific liquid chromatographic–electrospray mass spectrometry method for the determination of finasteride in human plasma and its application to pharmacokinetic study
This study developed and validated a reliable method to measure finasteride levels in human plasma, which was successfully used to assess its pharmacokinetics after a 5 mg dose in healthy volunteers.
research Impact of electrical impedance spectroscopy on dermatologists' number needed to biopsy metric and biopsy decisions for pigmented skin lesions
Electrical impedance spectroscopy improves biopsy accuracy and efficiency for skin lesions.