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Palliative chemotherapy is cost-effective for advanced gastric and colorectal cancer but not clearly for pancreatic-biliary cancer.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Dextran sulfate was found to be toxic and ineffective for treating HIV.

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

The conclusion is that the risk of losing significance in meta-analysis results increases with smaller effects and more missing data, and using the median standard deviation for imputation is recommended.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Stress can stop hair growth in mice, and treatments can reverse this effect.

Baldness is more common in Chinese men than women, increasing with age, and is influenced by genetics.

Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

MicroRNA-302 helps improve the conversion of body cells into stem cells by blocking NR2F2.

Eclipta alba extract improved learning, memory, and stress-related ulcers in rats without affecting movement or causing anxiety.

Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.

The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.

The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

People with alopecia areata often have other health issues like skin diseases, metabolic syndrome, stomach infections, lupus, anemia, thyroid problems, mental health issues, vitamin D deficiency, and hearing and eye problems.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Many people had severe allergic reactions to a common hair dye ingredient, causing them to seek medical care and miss work.

A cluster of sulfur-rich hair protein genes was found on chromosome 17.

Mutations in the PADI3 gene are linked to a higher risk of scarring hair loss in women of African descent.