September 2017 in “Journal of Investigative Dermatology” This study found that their novel 3D-imaging method, ASAXA-μCT, identified shrinkage of sweat glands as a key factor in skin aging, which leads to dermal defects, decreased elasticity, and increased wrinkling and sagging.
24 citations
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April 2017 in “Journal of Investigative Dermatology” This study identified sex-specific determinants for facial wrinkles, finding that age is the strongest factor and that lifestyle influences like smoking, alcohol use, and skin color differentially affect wrinkling in men and women.
July 2023 in “Photodermatology, Photoimmunology and Photomedicine” This review compiles existing research on infrared radiation's effects on human skin, noting both its potential harmful thermal impacts and encouraging therapeutic applications, but reports no new clinical results.
June 1996 in “Journal of Dermatological Science” Vitamin D3 applied to mouse skin caused more wrinkles and sagging due to changes in the skin's outer layer.
52 citations
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November 2006 in “International Journal of Cosmetic Science” This review discusses the identification and classification of different wrinkle types based on histological features and microanatomy, emphasizing their varying responses to treatments, and reports no new clinical results.
3 citations
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February 2025 in “Journal of PHYSIOLOGICAL ANTHROPOLOGY” This systematic review and meta-analysis found 30 genetic loci associated with skin ageing phenotypes, noting shared biological pathways in aspects like pigmentation and wrinkling; researchers suggest further studies targeting the same SNP across populations could clarify these associations.
23 citations
,
August 1987 in “Australasian Journal of Dermatology” In these studies, among 326 geriatric patients in Ottawa, the most common skin complaints were actinic keratoses, eczema, benign tumors, and malignant tumors.
Skin changes throughout life, from development before birth to aging effects like wrinkles, influenced by both genetics and environment.
4 citations
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November 2019 in “Harper's Textbook of Pediatric Dermatology” This article reviews the skin, hair, nail, and mucosal changes linked to various pediatric endocrine disorders but provides no new clinical findings.
July 2020 in “Nepalese journal of ophthalmology” This case report from Nepal describes a five-year-old boy with Hutchinson Gilford Progeria Syndrome experiencing ocular manifestations, highlighting the role of ocular senescence in this genetic disorder.
May 2015 in “Journal of Investigative Dermatology” Melanoma risk tools need improvement, a gene mutation causes a hair disorder that might be treated by managing cell stress, a potential therapy for a skin-ear disorder involves blocking cell channels, skin wrinkling may indicate lung aging regardless of smoking, and oxidative stress might contribute to common baldness.
January 2008 in “Summit (Simon Fraser University)” This article describes viDA Therapeutics Inc.'s focus on developing new drugs for age-related conditions using their proprietary granzyme-based approach but reports no clinical outcomes, primarily discussing their funding and business strategy.
January 2000 in “The Mouseion at the JAXlibrary (Jackson Laboratory)” This study identified a new mouse mutation associated with noninflammatory proliferative skin disease and hair abnormalities, drawing parallels to human conditions like Netherton's syndrome and monilethrix.
39 citations
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June 2017 in “Journal of Applied Research on Medicinal and Aromatic Plants” This review examines around 68 plant sources from six major plant families, assessing their scientific rationale and use by the cosmeceutical industry for applications like anti-ageing and sun protection.
March 2024 in “IP Indian journal of clinical and experimental dermatology” In this study conducted at a tertiary care center, rural elderly patients often exhibited skin conditions like wrinkling, generalized pruritus, xerosis, eczematous skin conditions, and psoriasis, highlighting the need for better health education on skin care, early diagnosis, and management.
87 citations
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March 2000 in “American Journal of Clinical Dermatology” Alpha-hydroxy acids, like glycolic acid, safely improve skin issues and work on all skin types.
14 citations
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October 2021 in “Dermatology and Therapy” This study found that photoexposure significantly increased the gene expression of altered elastin, MMP12, and LOX, as well as the protein expression of tropoelastin and fibrillin-1, in skin models.
3 citations
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October 2021 in “Letters in Applied NanoBioScience” This article explores the integration of nanotechnology and cosmetics, highlighting the development of cosmeceuticals targeting issues such as wrinkling, hyperpigmentation, and skin dehydration, while also reviewing cosmetic history and types of nanotechnology by particle size.
September 2023 in “International Research Journal of Modernization in Engineering Technology and Science” This article reviews the growing interest and potential health benefits of nutraceuticals, especially herbal products, highlighting their role in maintaining health, preventing diseases, and improving quality of life, while also discussing developments in nutraceutical research and challenges related to aging skin.
January 2019 in “International Journal of Research in Dermatology” This study observed that among elderly patients, pruritus was the most common cutaneous complaint, while physiological changes like wrinkling and pathological changes such as skin tumors and eczemas were frequent findings.
3 citations
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August 2017 in “Journal of evolution of medical and dental sciences” In this descriptive study, elderly patients most commonly presented with skin wrinkling, xerosis, and eczematous conditions, highlighting the difficulty in distinguishing normal age-related from pathological skin changes.
June 2020 in “IP Indian journal of clinical and experimental dermatology” This observational study reported that primary ageing dermatoses were more common than non-ageing dermatoses among elderly patients, especially among those with pre-existing skin conditions.
41 citations
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May 2018 in “Nutrition and healthy aging” This study suggests that age-related changes in skin elasticity reduce its stability against wrinkling, and anti-aging strategies should focus on addressing elastic mismatches between skin layers.
This article reviews how environmental factors and aging contribute to skin and hair changes, including wrinkling, dryness, pigmentation changes, and hair thinning, but reports no new research findings.
June 2020 in “International Journal of Research in Dermatology” In this study, xerosis was the most common skin condition found among elderly participants, followed by wrinkling and immunoglobulin heavy chain deposition.
175 citations
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November 2009 in “PLOS ONE” This study found that both genetic and environmental factors influence appearance-related aging in women, with skin wrinkling, hair graying, and sun damage significantly affecting perceived age more than chronological age.
June 2021 in “International journal of cosmetics and dermatology” This review found limited support for oral vitamin C and E in treating pigmentary disorders like chloasma, inflammatory conditions, and pressure wounds, with evidence constrained by small, varied studies.
November 2016 in “Journal of Evolution of Medical and Dental Sciences” This study observed that among elderly patients, the most common systemic disease associated with skin conditions was diabetes, while wrinkling and xerosis were prevalent skin changes.
150 citations
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April 2013 in “Dermato-endocrinology” This review discusses the effects of estrogen on skin aging and highlights potential therapies, but reports no new clinical findings.
June 2020 in “International journal of research in dermatology” This study found that oral intake of choline-stabilized orthosilicic acid (ch-OSA®) significantly improved hair, skin, and nail health in the Indian population, with no reported side effects.