In Vitro, Ex Vivo, and Clinical Evaluation of Anti-Aging Gel Containing EPA and CBD

June 2023 in “ Journal of cosmetic dermatology ”

Guy Cohen, Jeannette Jakus, M. Portillo, Raanan Gvirtz, Navit Ogen‐Shtern, Eldad Silberstein, T Ayzenberg, Sharon Rozenblat

cannabidiol CBD eicosapentaenoic acid EPA topical gel anti-aging skin moisture ROS formation dermatitis anti-inflammatory

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Studysummary This study found that a topical cream containing CBD and EPA reduced signs of extrinsic skin aging, including wrinkle volume and skin elasticity, in clinical and laboratory settings.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The research evaluated the anti-aging efficacy of a topical gel containing cannabidiol (CBD) and eicosapentaenoic acid (EPA) through in vitro, ex vivo, and clinical trials. The clinical trial involved 34 subjects aged 45-65. The gel showed potential in preventing, minimizing, and reversing the effects of accelerated aging, as evidenced by increased skin moisture, reduced ROS formation, and improved dermatitis. The gel also demonstrated anti-inflammatory action. The study concluded that the gel has significant anti-aging effects, with high patient satisfaction reported, and recommended long-term application for full benefits.

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Research cited in this study

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Efficacy and Tolerability of a Shampoo Containing Broad-Spectrum Cannabidiol in the Treatment of Scalp Inflammation in Patients with Mild to Moderate Scalp Psoriasis or Seborrheic Dermatitis

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14 citations , January 2020 in “Skin appendage disorders”

This study found that a shampoo containing 0.075% broad-spectrum cannabidiol significantly reduced scalp inflammation and symptoms in subjects with mild to moderate scalp psoriasis or seborrheic dermatitis within two weeks.

research Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter on Human Dermal Fibroblasts

68 citations , September 2018 in “International Journal of Molecular Sciences”

In this study, researchers found that exposure to PM10 significantly increased inflammation and impaired collagen synthesis in human dermal fibroblasts, suggesting PM10 contributes to skin aging through these mechanisms.