Development and Characterization of Dual-Loaded Niosomal Ion-Sensitive In Situ Gel for Ocular Delivery

    December 2024 in “ Gels ”
    Viliana Gugleva, Rositsa Mihaylova, Katya Kamenova, Dimitrina Zheleva‐Dimitrova, Denitsa Stefanova, Virginia Tzankova, Maya M. Zaharieva, Hristo Najdenski, Aleksander Foryś, Barbara Trzebicka, Petar Petrov, Denitsa Momekova
    TLDR The gel effectively delivers drugs to the eye, fights bacteria, and protects against oxidative stress.
    The study developed a dual-loaded niosomal ion-sensitive in situ gel for ocular delivery, incorporating cannabidiol (CBD) and epigallocatechin-3-gallate (EGCG) into a gellan gum-based gel. The formulation demonstrated high entrapment efficiency, suitable rheological properties, and sustained drug release, with a two-phase release profile. It showed significant antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and enhanced antioxidant potential, suggesting its promise as an ophthalmic drug delivery system. The gel also exhibited protective effects against oxidative stress in HaCaT cells, indicating potential benefits for treating bacterial infections and oxidative stress-related ocular diseases.
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