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In this study, knockout mice lacking the Cyp4f39 gene showed severe skin barrier dysfunction and high early mortality, suggesting its critical role in skin barrier formation and insights into ichthyosis pathogenesis.

The study found that cyproterone acetate-loaded nanostructured lipid carriers, particularly those with a 300 nm diameter, improved skin penetration and targeted hair follicles more effectively than free cyproterone acetate.

This article explains the structure and multifunctional roles of the human skin, including its protective, regulatory, and sensory functions, but does not report new research findings.

This study reports that among men, skin surface hydration and pH change with age, but transepidermal water loss and sebum production show less variation.

This study found that selective deletion of Ctip2 in epidermal keratinocytes in adult mice leads to atopic dermatitis-like inflammation and suggests Ctip2 plays a crucial role in skin barrier maintenance and inflammatory regulation.

This review discusses the role of the mineralocorticoid receptor in skin biology, highlighting its potential involvement in keratinocyte and hair physiology, and proposes it may affect the side effects of glucocorticoid use.

This review discusses the potential use of cultured primary fetal cells from a single organ donation to produce therapeutic products, emphasizing the need for process consistency and safety verification, but reports no clinical results.

This review found limited but suggestive evidence that Calcium Hydroxylapatite may promote skin regeneration through increased collagen production, cell proliferation, and angiogenesis, although most studies had methodological limitations.

This study found that a dopamine-methacrylated hyaluronic acid hydrogel enhances the efficacy of adipose-derived stem cells in promoting skin regeneration, potentially involving the Notch signaling pathway.

This study describes a protocol for generating hair-bearing skin organoids from human pluripotent stem cells, achieving full complexity resembling fetal skin tissue by day 130 in vitro.

This study found that the spiny mouse can regenerate tissues such as skeletal muscle, dermis, and hair without scarring after full thickness thermal burns, unlike the lab mouse.

This study found that 50-nm PLGA nanoparticles delivered with iontophoresis enhanced skin permeation of indomethacin in rats more effectively than 100-nm nanoparticles, suggesting improved targeting of hair follicles.

This study found that the contribution of the hair follicle pathway to skin permeation of chemicals can be predicted using lipophilicity, with hydrophilic chemicals showing greater permeation reduction from hair follicle plugging than lipophilic ones.

This review discusses skin tissue engineering and highlights the potential role of microRNAs in improving bioengineered skin equivalents, concluding that further exploration of microRNA targets could address unmet clinical needs.

This report reviews current advances in hair follicle regeneration for tissue-engineered skin grafts and highlights the feasibility and challenges of creating human hair follicles in this setting, suggesting key bioengineering requirements.

This review discusses the development and findings of 3D human skin models for studying melanocyte homeostasis and melanoma progression but reports no new clinical results.

This study found that using monoolein cubic phase nanoparticles with an entrapped hydroxypropyl β-cyclodextrin/minoxidil complex increased minoxidil skin permeation, but minoxidil retention in the skin was higher with a traditional solution.

Raspberry ketone may help grow hair and improve skin elasticity.

This review suggests that skin may largely protect itself from CYP-generated reactive metabolites due to higher conjugating enzyme activities, while highlighting limitations in modeling human skin metabolism experimentally.

This study demonstrated that implanting μm-scale full-thickness columns of human skin tissue into immunodeficient mice restored key features of normal human skin, suggesting potential for human wound repair with minimal donor site morbidity.

This study found that mice lacking alkaline ceramidase 1 with elevated skin ceramide levels showed disrupted skin homeostasis, including altered hair follicle structures, increased water loss, and a hypermetabolism phenotype.

This review explores the infundibulum's role and importance in skin diseases and emphasizes the need for further research into its biology and potential therapeutic targeting, but it presents no new findings.

Skin problems like acne, dry skin, and nail and hair changes are common in patients taking EGFR inhibitors.

Oestrogen and thyrotropin-releasing hormone affect prolactin and its receptor in human skin and hair, suggesting new treatment options for related conditions.

This study suggests that inflammation in the skin can exacerbate intestinal inflammation in inflammatory bowel diseases by activating fibroblasts in the colon through hyaluronan fragments released during skin inflammation.

This review discusses how acute exposures to environmental and internal stressors can quickly alter skin functions, leading to various dermatological symptoms, and calls for more research on these short-term effects.

This study explored the regenerative abilities of the African spiny mouse's skin, revealing more robust wound-induced hair follicle neogenesis compared to laboratory mice and highlighting unique features of its hair and wound response.

This review summarizes various effects of bergamot components on multiple health conditions in humans and animals but reports limitations in their use for stress and anxiety relief in aromatherapy.

This review explores the mechanisms of skin repigmentation and therapeutic strategies for pigmentation disorders following burn injuries, but it presents no new clinical results.

This article discusses isotretinoin for severe acne vulgaris, noting its effectiveness but also highlighting significant side effects on skin, mucous membranes, and hair; it reports no new clinical results.