29 citations,
July 2014 in “PloS one” Meis1 is crucial for skin health and tumor development.
10 citations,
February 2021 in “PLoS biology” Corin helps control salt and sweat release in sweat glands.
6 citations,
September 2019 in “Skin pharmacology and physiology” RCS-01 therapy is safe and may improve skin structure by affecting gene expression.
1 citations,
January 2023 in “International Journal of Molecular Sciences” Understanding how Regulatory T Cells work could help create treatments for certain skin diseases and cancers.
January 2012 in “Human health handbooks” The skin produces and uses vitamin D for bone health, cell growth, and immune function.
137 citations,
January 2006 in “Frontiers in bioscience” CRH in the skin acts like the body's stress response system, affecting cell behavior and immune activity.
124 citations,
February 2018 in “Nature Reviews Genetics” Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.
75 citations,
September 2009 in “Dermato-endocrinology” The skin produces and processes hormones, affecting both local and overall body functions.
31 citations,
April 2016 in “Nature communications” Certain signals are important for reducing specific chemical markers on hair follicle stem cells during rest periods, which is necessary for healthy hair growth.
Vitamin D is made by the skin, helps control various body functions, and affects skin health and immunity.
Erythropoietin overexpression disrupts hair growth and fat formation in mice.
326 citations,
February 2009 in “The American journal of pathology” Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.
6 citations,
November 2010 in “Histochemistry and cell biology” The proteins transthyretin and megalin are more present in the growth phase of hair, suggesting they might affect hair health and growth.
218 citations,
May 2014 in “Experimental Dermatology” Skin fat cells help with skin balance, hair growth, and healing wounds.
129 citations,
May 2015 in “Cell Stem Cell” Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
34 citations,
July 2020 in “American journal of human genetics” Changes in the SREBF1 gene cause a rare genetic skin and hair disorder.
7 citations,
March 2020 in “PloS one” α-parvin is necessary for skin and hair growth and for the correct orientation of skin cells.
3 citations,
January 2023 in “Regenerative Medicine” Exosomes show promise for skin and hair rejuvenation, but more research and regulation are needed before they can be widely used.
2 citations,
May 2023 in “International Journal of Molecular Sciences” The TRPV3 ion channel is important for skin and hair health and could be a target for treating skin conditions.
1 citations,
January 2019 in “Advances in stem cells and their niches” Epidermal stem cells are crucial for skin health and problems with them can cause issues like poor wound healing, cancer, and aging.
1 citations,
January 2013 Glucosylceramides are essential for healthy skin and proper wound healing.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” Melanocytes are cells that make skin and hair color and help protect skin from sun damage.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” SETDB1 is essential for controlling DNA methylation, silencing retrotransposons, and maintaining skin cell health, with its absence leading to skin inflammation and hair loss.
August 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” Krox20 is important for maintaining stem cells in the skin and affects hair growth and color.
August 2021 in “Journal of Investigative Dermatology” Adjusting polyamine levels could help treat skin disorders like psoriasis and skin cancer.
May 2015 in “Journal of Investigative Dermatology” Melanoma risk tools need improvement, a gene mutation causes a hair disorder that might be treated by managing cell stress, a potential therapy for a skin-ear disorder involves blocking cell channels, skin wrinkling may indicate lung aging regardless of smoking, and oxidative stress might contribute to common baldness.
28 citations,
December 2015 in “Journal of biological chemistry/The Journal of biological chemistry” Prostasin has two roles in skin: one for normal skin development without needing activation, and another for proper hair growth that requires activation.
14 citations,
February 2020 in “Scientific reports” Telocytes in the scalp may help with skin regeneration and maintenance.
February 2022 in “Research Square (Research Square)” LGR5 is a marker found in hair follicle stem cells in various species and is important for hair growth and skin repair.
September 2013 in “Experimental Dermatology” The document concluded that stem cells are crucial for skin repair, regeneration, and may help in developing advanced skin substitutes.