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Glossary Skin Function

protective barrier, temperature regulator, sensory organ, and vitamin D synthesizer

Skin function refers to the various roles that the skin plays in maintaining overall health and homeostasis. It acts as a protective barrier against environmental hazards like pathogens and UV radiation, regulates body temperature through sweat and blood flow, and enables sensory perception. Additionally, the skin is involved in the synthesis of vitamin D and plays a role in immune response.

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research Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin

9 citations , August 2021 in “International journal of molecular sciences”

This study found that loss of epidermal PPARγ in mice altered the expression of many genes related to skin inflammation, keratinization, and sebaceous gland function, indicating its key role in maintaining skin homeostasis.

research The Role of PGC-1α in Aging Skin Barrier Function

8 citations , July 2024 in “Cells”

In this review, researchers explored how PGC-1α might improve aged skin barrier function by influencing mitochondrial function and reducing inflammation, factors that are linked to epidermal health during aging.

Circadian Rhythms on Skin Function of Hairless Rats: Light and Thermal Influences

research Circadian rhythms on skin function of hairless rats: light and thermic influences

8 citations , March 2014 in “Experimental Dermatology”

Light and temperature affect the daily skin function rhythms in hairless rats, with temperature influencing water loss but not skin hydration.

research Structure and Function of the Skin

6 citations , January 2009 in “Elsevier eBooks”

This chapter discusses the structure and function of the skin, detailing its protective roles and the layers that comprise it, but reports no new research findings.

research Iron and skin health: iron stimulates skin function

4 citations , January 2012 in “Human health handbooks”

This study suggests that ferrous ferric chloride plays a role in regulating skin homeostasis by promoting the proliferation and differentiation of skin cells from a distance.

research The Function and Structure of the Skin

4 citations , November 2014

The skin protects the body, regulates temperature, senses touch, and makes vitamin D.

Interrelationships Between Skin Structure, Function, and Microbiome of Pregnant Females and Their Newborns: Study Protocol for a Prospective Cohort Study

research Interrelationships between Skin Structure, Function, and Microbiome of Pregnant Females and Their Newborns: Study Protocol for a Prospective Cohort Study

January 2021 in “Dermatology Research and Practice”

This study will explore skin and hair characteristics of pregnant women and their newborns, examining the relationships between these factors and the newborns' skin maturation over time.

research Structure and function of the skin

August 2021 in “Oxford University Press eBooks”

This chapter discusses various skin functions and structures involved in protection, immune response, and homeostasis, but it reports no new research findings.

research Photosensory Function, Reception and Response in Human Skin

January 2021 in “Journal of clinical and cosmetic dermatology”

This review highlights the role of the skin's photosensory system in mediating responses to UVA radiation, contributing both to immediate protective effects and to broader circadian and seasonal adaptations, but reports no new experimental results.

Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions

research Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial–Mesenchymal Interactions

56 citations , March 2015 in “Journal of Investigative Dermatology”

Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.

research Skin: Basic Structure and Function

36 citations , January 2014 in “Elsevier eBooks”

This narrative review discusses the structure and functions of the skin, focusing on its barrier role, self-repair, thermoregulation, and immune functions, and reports no new experimental results.

research Oestrogen functions in skin and skin appendages

68 citations , June 2005 in “Expert Opinion on Therapeutic Targets”

This review discusses the influence of oestrogens on various skin components and highlights their modulatory roles and receptor pathways, but it reports no new clinical results.

research The role of activins and follistatins in skin and hair follicle development and function

45 citations , October 2008 in “Cytokine & Growth Factor Reviews”

This review discusses the role of activin signaling in hair follicle formation, hair growth cycling, and skin healing, but presents no new clinical findings.

research STRUCTURAL-FUNCTIONAL REORGANIZATION OF SKIN AND ITS DERIVATIVES UNDER EXPERIMENTAL SUBACUTE OF INTOXICATION BY HEAVY METALS

1 citations , March 2019 in “Hygiene and Sanitation”

This study observed that exposure to heavy metal salts affected skin and hair morphology in mice, with lead acetate decreasing keratinocyte proliferation and zinc sulfate and sodium dichromate increasing it.

research Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions

84 citations , May 2008 in “Biological Chemistry”

This review discusses the roles of human tissue kallikreins in skin physiology and pathology and reports no new findings, emphasizing their potential involvement in various skin functions and conditions.

JunB Defines Functional And Structural Integrity Of The Epidermal-Pilosebaceous Unit In The Skin

research JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin

48 citations , August 2018 in “Nature Communications”

This study found that JunB, a transcription factor, is crucial for maintaining epidermal-pilosebaceous stem cell homeostasis by regulating progenitor cell behavior and preventing sebaceous gland dysfunction.

research Functional Skin Grafts: Where Biomaterials Meet Stem Cells

43 citations , July 2019 in “Stem Cells International”

This review discusses advances and challenges in skin tissue engineering, focusing on developing 3D constructs for functional skin substitutes, and reports no new clinical results.

research TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function

22 citations , September 2011 in “Journal of Investigative Dermatology”

This study found that impaired TCF/Lef1 signaling in mice leads to significant skin barrier defects due to altered lipid metabolism and epidermal differentiation.

research Structure and Function of the Skin

1 citations , January 2012 in “Elsevier eBooks”

The document concludes that the skin is a complex organ providing protection, sensation, and healing, with challenges in treating conditions like itchiness.

research Functional analysis of the stratum corneum of scalp skin: studies in patients with alopecia areata and androgenetic alopecia

52 citations , December 2000 in “Archives of Dermatological Research”

This study found that the stratum corneum of scalp skin in humans has distinct functional characteristics compared to the facial skin and volar forearm, including higher hydration levels and intermediate epidermal turnover rates.

research Anatomy and Function of the Skin

40 citations , January 2016 in “Elsevier eBooks”

This article explains the structure and multifunctional roles of the human skin, including its protective, regulatory, and sensory functions, but does not report new research findings.

research Caffeine improves barrier function in male skin

33 citations , September 2006 in “International Journal of Cosmetic Science”

This study found that applying caffeine significantly improved the skin barrier function of male volunteers by reducing transepidermal water loss compared to female volunteers.

research Expression and Function of Group IIE Phospholipase A2 in Mouse Skin

26 citations , May 2016 in “Journal of biological chemistry/The Journal of biological chemistry”

This study found that mice lacking sPLA2-IIE had distinct skin abnormalities, particularly affecting hair follicles, highlighting the differing roles of sPLA2 isoforms in mouse skin.

research Hair follicles modulate skin barrier function

9 citations , June 2024 in “Cell Reports”

This study found that hair follicles play a significant role in regulating skin barrier function, with disruptions in the upper hair follicle affecting the epidermis, influencing processes like desquamation and sebum release, and leading to cell movement into the epidermis.

research Physiological skin oxygen levels: An important criterion for skin cell functionality and therapeutic approaches

5 citations , June 2024 in “Free Radical Biology and Medicine”

This review highlights that current in vitro models often fail to replicate the physiological oxygen levels experienced by different skin cell types, which could affect redox states and functions, potentially accelerating skin aging.

research Skin fibroblast functional heterogeneity in health and disease

1 citations , August 2023 in “The Journal of Pathology”

In this source, recent single-cell RNA-sequencing advances reveal significant transcriptional heterogeneity among skin fibroblasts, and the discussion focuses on the distinct subtypes' roles in skin homeostasis, repair, and their evolution in fibrotic diseases like keloid scars and cancer.

research Advantages of Functional Foods in Supporting and Maintaining Hair and Skin Health

1 citations , January 2023

This article reviews the potential benefits of functional foods and natural products for skin and hair health but presents no new clinical findings.

research Dietary sodium hyaluronate and eggshell membrane improve skin barrier function and coat health in Ragdoll cats

July 2026 in “Frontiers in Veterinary Science”

This study found that combined dietary supplementation of sodium hyaluronate and eggshell membrane was associated with various improvements in skin and coat health markers in healthy Ragdoll cats.

research 火针联合水杨酸对痤疮患者皮肤屏障功能及微生态的影响（The impact of fire needle therapy combined with salicylic acid on the skin barrier function and microecology of patients with acne）

January 2025 in “中医药研究与应用（Research and application of traditional Chinese medicine）”

In this study involving acne patients, researchers compared the effects of combined fire needle and salicylic acid therapy with conventional treatment, measuring improvements in skin lesion severity, skin barrier function, and microbiota diversity; results are not reported in the abstract.

research 371 Hair follicles are critical modulators of skin barrier function

July 2024 in “Journal of Investigative Dermatology”

Hair follicles are crucial for maintaining skin barrier function.