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Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

MIM is crucial for hair follicle formation and regeneration by controlling cilia formation and hedgehog signaling through its interaction with Cortactin and Src.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

Skin-derived precursors in hair follicles come from different origins but function similarly.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.

Treatments for melanin disorders exist, but more effective options needed.

A certain smell receptor in hair follicles can affect hair growth when activated by a synthetic sandalwood scent.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Certain genes control the color of human hair by affecting pigment production.

The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.

Smart biomaterials that guide tissue repair are key for future medical treatments.

SHISA6 helps maintain certain stem cells in mouse testes by blocking signals that would otherwise cause them to differentiate.

Mesenchymal stem cells show potential for skin healing and anti-aging, but more research is needed for safe use, especially regarding stem cells from induced pluripotent sources.

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.