HDL as Therapeutic Tools

January 2019 in “ Springer eBooks ”

Kyung-Hyun Cho

reconstituted high-density lipoprotein rHDL V156K variant apoA-I adenoviral vectors gene delivery rapamycin minoxidil antioxidant ability anti-senescence effects CETP inhibition human dermal fibroblast cells cell growth tissue regeneration HDL Rogaine

From the encyclopedia

Rapamycin →

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Studysummary Modified HDL can better deliver drugs and genes, potentially improving treatments and reducing side effects.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Alopecia Areata: A Multifactorial Autoimmune Condition

148 citations , December 2018 in “Journal of autoimmunity”

This review discusses genetic and environmental factors contributing to autoimmunity in alopecia areata and reports no new clinical findings, emphasizing the need for further study on its aetiology and pathophysiology.

research JAK Inhibitors: New Players in the Field of Immune-Mediated Diseases Beyond Rheumatoid Arthritis

223 citations , September 2018 in “Rheumatology”

This review examines clinical data on the efficacy and safety of JAK inhibitors used for immune-mediated conditions beyond rheumatoid arthritis, highlighting their potential therapeutic roles in various inflammatory diseases.

research Metabolic Syndrome and the Skin: A More Than Superficial Association

52 citations , February 2018 in “Diabetology & Metabolic Syndrome”

This review discusses the association between various skin conditions and metabolic syndrome, reporting no new clinical results but suggesting a potential reciprocal relationship that warrants further investigation.

research Lipid Profile in Patients with Androgenetic Alopecia: A Meta-Analysis

15 citations , October 2016 in “Journal of The European Academy of Dermatology and Venereology”

This meta-analysis found that patients with androgenetic alopecia have significantly abnormal lipid profiles, which could contribute to the link between this condition and cardiovascular diseases.

research Association of Metabolic Syndrome With Female Pattern Hair Loss in Women: A Case-Control Study

21 citations , April 2016 in “International Journal of Dermatology”

This study found a significant association between female pattern hair loss and metabolic syndrome in Egyptian women, with waist circumference and hypertension particularly linked to the severity of hair loss.

Both Low Circulating Insulin-Like Growth Factor-1 and High-Density Lipoprotein Cholesterol Are Associated with Hair Loss in Middle-Aged Women

research Both Low Circulating Insulin-Like Growth Factor-1 and High-Density Lipoprotein Cholesterol Are Associated with Hair Loss in Middle-Aged Women

6 citations , March 2016 in “British Journal of Dermatology”

This study reports that low levels of HDL cholesterol and IGF-1 were associated with a higher risk of hair loss in middle-aged women, but causal relationships remain uncertain.

research Is Early Onset Androgenic Alopecia a Marker of Metabolic Syndrome and Carotid Artery Atherosclerosis in Young Indian Male Patients?

24 citations , January 2015 in “International Journal of Trichology”

This research observed that among young men with androgenic alopecia, there was a significant association with metabolic syndrome compared to healthy controls, suggesting AGA as a potential early marker for metabolic risk.

research Clinical Utility and Validity of Minoxidil Response Testing in Androgenetic Alopecia

43 citations , August 2014 in “Dermatologic Therapy”

This study confirmed that a sulfotransferase enzyme test can effectively rule out 95.9% of nonresponders to 5% topical minoxidil for treating androgenetic alopecia.

research Early Stage Alopecia Areata Is Associated With Inflammation in the Upper Dermis and Damage to the Hair Follicle Infundibulum

22 citations , June 2013 in “Australasian Journal of Dermatology”

Early stage bald spots are linked to skin inflammation and damage to the upper part of the hair follicle.

research Topical Minoxidil for Hair Regrowth

80 citations , September 1984 in “Journal of The American Academy of Dermatology”

In this study, 5% topical minoxidil was observed to promote hair regrowth in some patients with androgenic alopecia, while no regrowth was noted in patients with alopecia areata.