TLDR Modified HDL can better deliver drugs and genes, potentially improving treatments and reducing side effects.
The document from 2019 explores the use of reconstituted high-density lipoprotein (rHDL) as a vehicle for drug and gene delivery, focusing on its potential to improve therapeutic outcomes and reduce side effects. The study found that rHDL containing the V156K variant of apoA-I, a protein component of HDL, enhanced the stability and delivery efficiency of adenoviral vectors for gene delivery and increased the solubility of poorly water-soluble drugs like rapamycin and minoxidil. Specifically, V156K-rapa-rHDL showed enhanced antioxidant ability and anti-senescence effects, with a 29% inhibition of CETP at 10 µM rapamycin and reduced cellular senescence in human dermal fibroblast cells. For hair loss treatment, rHDL was used to solubilize minoxidil, resulting in a fivefold increase in solubility, improved antioxidant activity, and enhanced cell growth and tissue regeneration, with the V156K-minoxidil-rHDL variant showing the strongest effects. The study, which included experiments performed in duplicate and three independent experiments with seven subjects each, suggests that rHDL could be an efficient delivery system for drugs and genes, with the V156K mutation offering additional benefits.View this study on link.springer.com →
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People with hair loss have worse cholesterol levels, possibly linking hair loss to heart problems.
Low IGF-1 and high HDL cholesterol levels are linked to more hair loss in middle-aged women.
Metabolic syndrome linked to female hair loss; waist size and high blood pressure important factors.
Early balding in young Indian men may indicate a higher risk of metabolic syndrome and potential heart disease.
Minoxidil response testing helps treat hair loss effectively and safely.
Early stage bald spots are linked to skin inflammation and damage to the upper part of the hair follicle.
Balding men, especially young ones, may have higher risk of heart issues and diabetes; check cholesterol levels.
People with early onset baldness have higher bad cholesterol and lower good cholesterol, increasing their heart disease risk.
Early hair loss may indicate risk of insulin resistance.
Minoxidil slows down skin cell growth and may help treat scars and skin conditions.
5% minoxidil helps hair regrowth in androgenic alopecia.