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This study developed a bilayer bionic skin scaffold that mimics the skin's structure to resist microbial invasion and enhance wound healing, with in vivo animal studies showing improved collagen deposition, neovascularization, and hair follicle formation.

This review highlights silk fibroin and its nanocomposites as promising materials for wound healing, addressing challenges in chronic wound treatment, especially in developing countries, and examines the obstacles in bringing silk-based products to market.

This review explores how recombinant protein hydrogels, employing molecular engineering and crosslinking strategies, offer advanced applications in regenerative medicine by mimicking extracellular matrix dynamics and providing enhanced mechanical, environmental, and biological properties.

In this review, researchers evaluated sericin-based drug delivery systems for antimicrobial, anticancer, and neurodegenerative treatments, highlighting its potential benefits and challenges related to molecular variability and formulation stability, suggesting future focus on optimizing extraction and integration with advanced biomedical technologies.

This study systematically analyzed the molecular and cellular mechanisms of wound healing and assessed the market potential for wound healing products based on natural proteins, projecting significant growth by 2033.

This review examines advancements in "smart" hydrogel dressings for complex wound healing, highlighting innovations in materials that provide multifunctionality, such as responsive drug delivery and regenerative capabilities. The study also addresses potential challenges in clinical application, like manufacturing and regulatory hurdles.

This paper reviews the benefits of using silk proteins as natural ingredients in cosmetics, highlighting their potential for improving skin and hair health due to properties like antimicrobial activity, UV resistance, and enhanced moisture absorption.

Sericin hydrogels heal skin wounds well, regrowing hair and glands with less scarring.

In this study, the RADA-PRG hydrogel enhanced SKP proliferation, survival, and gene expression, effectively supporting hair follicle regeneration in mice.

In this study, a newly developed nanoparticle-loaded hydrogel wound dressing demonstrated significant antibacterial, antioxidant, anti-inflammatory, and proangiogenic activities, effectively reducing pain and promoting healing in a murine burn wound model while preventing infection by *Staphylococcus aureus*.

This study found that silk fibroin/sodium alginate scaffolds seeded with dermal papilla cells may accelerate skin repair and hair follicle regeneration in a rat model.

This review discusses recent advancements in hair follicle organoid technology for alopecia treatment but presents no new experimental results, emphasizing the potential for clinical applications and drug screening.

This study found that sericin dressing containing collagen hydrolysate significantly reduced wound healing time and improved scar quality compared to commercial dressing in split-thickness skin graft donor sites.

This research found that keratin hydrogels derived from human hair may support cell viability and proliferation, indicating potential as 2D and 3D soft tissue culture scaffolds.

This review discusses photothermal agent hybrids in hydrogels for antibacterial action, angiogenesis, and osteogenesis in tissue engineering, but reports no new experimental findings.

This study found that 'smart' peptide hydrogels improved wound healing in a rat model of partial thickness burns, achieving greater wound closure and faster debridement compared to a standard treatment.

This study suggests that adjusting the ratios of keratin-associated proteins to keratin intermediate filaments can create keratin/chitosan hydrogels with more consistent gel properties for tissue engineering.

This study explored a keratin, sodium alginate, and carboxymethyl chitosan hydrogel modified with tannic acid and found it to have promising wound-healing qualities, including similar elasticity to human skin, antimicrobial and antioxidant properties, and effective water retention. These attributes suggest potential applications in biomedical engineering.

This study found that mupirocin nanoparticle-loaded hydrogel was safe and more effective for healing burn wounds in rats compared to mupirocin ointment, showing promise for future clinical trials.

This study suggests that human dermal fibroblasts can be converted into dermal papilla cell-like cells using microencapsulation, which may facilitate hair follicle regeneration in mice without chemical or genetic reprogramming.

This review highlights recent advancements in the engineering of skin organoids using hydrogels, which improve their structural and functional fidelity by supporting the architecture and integration of vascular and neural components, promising to enhance regenerative medicine, drug discovery, and complex skin disorder studies.

This research highlights a hydrogel system that could significantly improve diabetic wound healing by releasing ibuprofen to both suppress inflammation and promote tissue regeneration, indicating a strong potential for future clinical use.

This review discusses advancements and challenges in using 3D bioprinting for diabetic foot ulcer treatments, highlighting potential improvements and existing limitations in replicating skin architecture and clinical application.

This research concluded that the novel hydrogel PlacMA, derived from human placenta and curable by visible light, shows promise for cell culture and tissue engineering applications due to its tunable properties.

In this study, small molecule-loaded silk fibroin nanofiber scaffolds with chitosan achieved sustained release of GSK-3 inhibitor SB216763, leading to enhanced wound healing and hair follicle neogenesis in skin regeneration efforts.

This study found that keratin hydrogels extracted from human hair showed potential as biodegradable and biocompatible filler materials, promoting angiogenesis and cell proliferation in rat models.

This study investigated various proteins as eco-friendly hair perming agents for Asian hair and found that bovine serum albumin and keratin achieved perming results comparable to commercial products, while also increasing hair moisture, indicating a protective effect during heat styling.

This chapter discusses the composition, biocompatibility, and production methods of biomaterials like collagen, chitin, and silk for dermal substitutes, focusing on preclinical and clinical research, but reports no new clinical results.

This study reports that Echinacea-loaded silk fibroin/chitosan dressings may effectively promote scarless skin regeneration and accelerate wound healing compared to conventional treatments.

This review discusses the potential of hydrogel-based interventions for radiation-induced skin injury, providing no new clinical results but highlighting their synergistic mechanisms and promise in improving treatment strategies.