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Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

The ZIP7 gene helps control zinc levels in cells by moving zinc from the Golgi apparatus to the cytoplasm.

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

Special fiber materials boost the healing properties of certain stem cells.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

Pectin biosynthesis is essential for the growth of cotton fibers and Arabidopsis root hairs.

Fibromodulin might help reduce scarring if increased in adult wounds like in fetal skin that heals without scars.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.