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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Androgens can both increase and decrease hair growth in different parts of the body.

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

Targeted cancer therapies often cause serious skin problems that need careful management.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Humans lost body hair relatively recently in evolution.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Male pattern hair loss could hint at androgens affecting COVID-19 severity.

Obesity is linked to various skin problems and may increase the risk of skin cancer.

Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

Giving a special protein to dogs with a certain genetic disease improved their symptoms but didn't help with hair growth.

Thymus transplantation successfully restored immune function in infants with FOXN1 deficiency.

Male pattern hair loss is genetic and influenced by hormones, with treatments like minoxidil and surgery available.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.