17 citations
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November 2018 in “Dermatology” The authors concluded that Hispanic/Latino ethnicity, facial papules, and premenopausal status in patients with frontal fibrosing alopecia may indicate a susceptibility to more severe disease, potentially necessitating early treatment.
339 citations
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February 2014 in “Journal of The American Academy of Dermatology” This study found that eyelash loss, facial papules, and body hair involvement were linked to severe frontal fibrosing alopecia, and antiandrogens were the most effective treatment.
4 citations
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January 2019 in “Acta dermato-venereologica” This study found that women with frontal fibrosing alopecia have a significantly higher prevalence of rosacea compared to controls, particularly those with severe alopecia, and certain factors like perifollicular erythema, higher BMI, and lower progesterone levels were linked to increased rosacea risk.
In this observational study, dutasteride treatment was associated with statistically significant stabilization of frontal fibrosing alopecia compared to other systemic therapies, with a dose-dependent effect observed across the frontal and bilateral temporal hairlines.
22 citations
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January 2017 in “Skin appendage disorders” This research analyzed 72 primary scarring alopecia cases in a Barcelona hospital, finding that the majority involved women, with a lymphocytic infiltrate and subacute onset in many cases, leading to stable disease, while neutrophilic cases had more acute episodes.
36 citations
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December 2017 in “Journal of the American Academy of Dermatology” This study observed that 70.7% of patients with frontal fibrosing alopecia stabilized with treatment, and patients using 0.3% tacrolimus were more likely to stabilize in 3 months compared to other treatments.
16 citations
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April 2020 in “JAMA dermatology” More inflammation leads to faster and worse hair loss in women with frontal fibrosing alopecia.
January 2026 in “Advances in Dermatology and Allergology” In this study, patients with lichen planopilaris and frontal fibrosing alopecia reported a substantial impairment in quality of life and experienced high levels of stress, often considering stress a cause of their condition.
November 2018 in “Skin appendage disorders” The document concludes that a woman has both Frontal Fibrosing Alopecia and Lichen Simplex Chronicus, a previously unreported combination of conditions.
This study reported that prompt diagnosis and treatment with 5-alpha-reductase inhibitors and topical immunomodulators are key to mitigating the effects of frontal fibrosing alopecia and preventing permanent hair loss.
5 citations
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January 2021 in “Skin appendage disorders” This review summarizes evidence suggesting that smoking is associated with alopecia and premature hair graying, with smokers showing higher prevalence than nonsmokers.
5 citations
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March 2014 in “Journal of The American Academy of Dermatology” The study suggests hormonal factors may play a role in Frontal Fibrosing Alopecia and that treatments like oral antiandrogens and steroids could be beneficial.
21 citations
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October 2017 in “Journal of the European Academy of Dermatology and Venereology” This study reports that variable environmental factors, including dietary habits, may contribute to the increasing incidence and diverse clinical presentations of frontal fibrosing alopecia.
17 citations
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January 2020 in “Skin appendage disorders” This review suggests that the Mediterranean diet, protein-rich diets, and soy may support hair health in nonscarring alopecias like androgenetic alopecia.
12 citations
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July 2020 in “Actas Dermo-Sifiliográficas” This study found that facial papules and rosacea in patients with frontal fibrosing alopecia were linked to a greater need for oral treatment, with most cases involving postmenopausal women.
3 citations
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February 2022 in “Dermatology practical & conceptual” This study found that trichoscopy is an effective noninvasive technique for diagnosing frontal fibrosing alopecia, confirming its valuable role alongside traditional histopathological examination.
3 citations
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February 2017 in “The American journal of dermatopathology/American journal of dermatopathology” This case report details a 73-year-old woman with systemic sarcoidosis, whose scalp biopsy revealed features consistent with both sarcoidosis and frontal fibrosing alopecia, emphasizing the necessity of biopsy in complex alopecia diagnoses.
2 citations
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February 2025 in “Journal of the European Academy of Dermatology and Venereology” This study suggests that Janus kinase inhibitors may offer a potential treatment option for refractory lichen planopilaris and frontal fibrosing alopecia, showing positive response rates between 42% and 100%, though evidence quality is low.
2 citations
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January 2023 in “Journal of Clinical Medicine” This review discusses the links between different types of alopecia and thyroid disorders, highlighting some shared autoimmune factors, but reports no new clinical results.
July 2026 in “Applied Sciences” This review suggests that 308 nm excimer therapy may offer a well-tolerated non-pharmacologic option for alopecia areata, with more limited evidence for its effectiveness in lichen planopilaris and frontal fibrosing alopecia.
December 2025 in “Actas Dermo-Sifiliográficas” This consensus from 22 Spanish dermatologists recommends using a multimodal therapy starting with oral dutasteride, combined with topical and/or intralesional agents, and adding hydroxychloroquine if inflammation persists, to manage frontal fibrosing alopecia due to its irreversible hair loss and lack of specific approved treatments.
October 2024 in “JEADV Clinical Practice” This study reports the prescribing preferences of UK dermatologists for treating various hair loss conditions, noting that topical corticosteroids for mild to moderate alopecia areata and topical minoxidil for female pattern hair loss are commonly used first-line treatments.
September 2023 in “JEADV Clinical Practice” This study reviewed existing literature and found that androgenic alopecia may be associated with cardiovascular risk factors, while evidence for alopecia areata and cicatricial alopecias is limited and sometimes contradictory.
March 2014 in “Journal of The American Academy of Dermatology” Mycophenolic acid may help hair growth, a combination treatment improves hair thickness in male hair loss, and early treatment of frontal fibrosing alopecia is important.
9 citations
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January 2023 in “Journal of Clinical Medicine” This study presents a validated questionnaire, the FFA-QLI, which effectively assesses and differentiates the quality of life impact among patients with frontal fibrosing alopecia, showing greater sensitivity in identifying severe cases than the DLQI.
In this open uncontrolled study on microneedling as an adjuvant therapy for frontal fibrosing alopecia, researchers observed stable frontotemporal recession measurements while patients reported improvements in quality of life and a reduction in inflammatory activity parameters.
1 citations
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April 2017 in “Journal of Investigative Dermatology” In this study, D-OCT imaging revealed distinct structural and vascular changes in patients with frontal fibrosing alopecia, highlighting the technique's potential for diagnosing and monitoring the condition's activity.
2 citations
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April 2018 in “Journal of Investigative Dermatology” This study suggests that frontal fibrosing alopecia is a highly inflammatory disease involving TH1 and JAK-STAT pathways, without reduced hair keratins, highlighting JAK-STAT signaling as a potential therapeutic target.
14 citations
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June 2021 in “British journal of dermatology/British journal of dermatology, Supplement” This paper presents consensus guidelines for standardized diagnostic criteria and assessment methods for frontal fibrosing alopecia to improve clinical research and data collection globally.
April 2017 in “Journal of Investigative Dermatology” This study observed that using a 1064 nm Nd: YAG laser may stabilize hair loss and promote new growth in some females with frontal fibrosing alopecia, though individual results varied.