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    Did you mean Severe Combined Immunodeficient Mice?
    Glossary Severe Combined Immunodeficient Mice

    laboratory mice with a genetic mutation causing a nonfunctional immune system

    Severe Combined Immunodeficient (SCID) mice are laboratory mice that lack a functional immune system due to a genetic mutation. This makes them highly valuable in scientific research, particularly for studying human diseases, testing new drugs, and conducting cancer research, as they can accept human cells and tissues without rejecting them.

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    1. Histologic and Cell Kinetic Studies of Hair Loss and Subsequent Recovery Process of Human Scalp Hair Follicles Grafted onto Severe Combined Immunodeficient Mice Journal of Investigative Dermatology · 2000 · 31 citations
    2. FOXN1 deficient nude severe combined immunodeficiency Orphanet journal of rare diseases · 2017 · 32 citations
    3. Epstein-Barr virus associated with high-grade B-cell lymphoma in nude severe combined immunodeficiency BMJ case reports · 2019 · 3 citations
    4. Skin Manifestations in Primary Immunodeficient Children Pediatric Dermatology · 2011 · 57 citations
    5. Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations Journal of Clinical Immunology · 2021 · 30 citations
    6. Ectrodactyly, Ectodermal Dysplasia, and Cleft Lip/Palate Syndrome with Concomitant Lymphopenia: A Novel TP63 Mutation 2016
    7. 080 Mouse models of alopecia areata: C3H/HeJ mice versus the humanized AA mouse model Journal of Investigative Dermatology · 2019
    8. T Cell Immunodeficiency, Congenital Alopecia, and Nail Dystrophy 2022
    9. Alymphoid cystic thymic dysgenesis - FOXN1 gene mutation: a rare case report of two siblings International journal of contemporary pediatrics · 2020
    10. Advances in genetic and molecular understanding of Omenn syndrome - implications for the future Expert opinion on orphan drugs · 2018 · 2 citations
    11. Human ClinicalPhenotype Associated with FOXN1 Mutations Advances in experimental medicine and biology · 2009 · 22 citations
    12. A New Humanized Mouse Model for Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2013 · 25 citations
    13. Decision‐Making Regarding the Administration of Live Vaccines to Patients With a <i>FOXN1</i> Heterozygous Missense Variant Pediatrics International · 2026
    14. Early skin biopsy is helpful for the diagnosis and management of neonatal and infantile erythrodermas 2010
    15. Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2 Frontiers in immunology · 2019 · 98 citations
    16. TREATMENT OF ALOPECIA AREATA WITH ORAL METHYLPREDNISOLONE COMBINED WITH FRACTIONAL MICRONEEDLE RADIOFREQUENCY Tạp chí Da liễu học Việt Nam · 2025
    17. FOXN1 Deficiency: from the Discovery to Novel Therapeutic Approaches Journal of clinical immunology · 2017 · 33 citations
    18. A clinical case of familial alopecia areata in combination with immune pathology Russian Journal of Clinical Dermatology and Venereology · 2025
    19. Mucocutaneous manifestations in children with human immunodeficiency virus infection Indian Journal of Dermatology, Venereology and Leprology · 2010 · 16 citations
    20. Management of hair loss after severe acute respiratory syndrome coronavirus 2 infection: Insight into the pathophysiology with implication for better management The Journal of Dermatology · 2022 · 7 citations
    21. MOUSE MODELS FOR THE STUDY OF HUMAN HAIR LOSS Dermatologic Clinics · 1996 · 36 citations
    22. Cutaneous signals of immune system disease Current problems in dermatology · 1991
    23. Histologic Study of the Regeneration Process of Human Hair Follicles Grafted onto SCID Mice after Bulb Amputation Journal of Investigative Dermatology Symposium Proceedings · 2001 · 19 citations
    24. Cutaneous reactions to recombinant cytokine therapy Journal of The American Academy of Dermatology · 1995 · 105 citations
    25. Disentangling the Coronavirus Disease 2019 Health Disparities in African Americans: Biological, Environmental, and Social Factors Open Forum Infectious Diseases · 2021 · 28 citations
    26. Hypertensive crisis associated with St. John’s Wort The American Journal of Medicine · 2002 · 37 citations
    27. Dermatologic therapy: December 1987 to December 1988 Journal of The American Academy of Dermatology · 1990
    28. Malarone® induced pancreatitis and alopecia in a dog: a case report BMC veterinary research · 2019 · 1 citations
    29. FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program Frontiers in Immunology · 2013 · 69 citations
    30. Clinical Efficacy and Safety of Baricitinib in Patients With Alopecia Areata in Korea Annals of Dermatology · 2025 · 1 citations