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Spironolactone can cause side effects like high potassium levels and breast enlargement, and patients need careful monitoring.

Eflornithine's effectiveness for women with facial hirsutism is unclear.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

PCOS is caused by both genetics and environmental factors like diet and obesity.

Oestrogens are key for bone growth during puberty in both boys and girls.

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

DHT may increase the risk of heart disease and death in elderly men.

Voriconazole can cause serious side effects, especially in long-term use.

Lower SHBG levels may increase the risk of PCOS.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Women with PCOS have higher androgen levels that decrease with age but are still higher than in women without PCOS.

Dienogest combined with ethinylestradiol is a highly effective birth control that improves menstrual symptoms and has manageable side effects.

SHBG may be a useful early indicator and treatment target for PCOS.

A boy with severe Vitamin D-resistant rickets did not respond to treatment and lacked a common symptom, suggesting a need for alternative treatments.

Androgens significantly affect female hair loss, and hormonal treatments may help.

Silicon can improve skin and hair health, but more research is needed.

Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.

The testosterone patch and gel are both effective, but they have different absorption patterns and effects on hormone levels.

Natural molecules like inositols, resveratrol, vitamins, and omega-3 fatty acids may help manage Polycystic Ovary Syndrome (PCOS), but their effects vary and need more exploration.

Combining cyclosporine A and ketoconazole can effectively treat anal furunculosis in dogs, with some experiencing recurrences and mild side effects.

Extended-release divalproex is better tolerated and more effective for seizures and psychiatric symptoms than delayed-release divalproex, but doesn't reduce hair loss.

Low and ultralow doses of flutamide can cause liver damage in young women with high androgen levels, regardless of dose or birth control use, with higher risk for those with higher BMI and liver enzyme levels before treatment.

Male faces age with more wrinkles and hair loss, influenced by both body changes and environmental factors.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.