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After severe COVID-19, 71% of patients experienced excessive hair shedding and thinning within 3 months due to factors like low oxygen levels, medication, stress, and autoimmune disease.

Netherton syndrome can cause severe dehydration, infections, and growth issues in infants.

Cornification is the process where living skin cells die to create a protective barrier, and problems with it can cause skin diseases.

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

Male pattern hair loss could hint at androgens affecting COVID-19 severity.

Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.

Skin problems in COVID-19 patients are rare and may be due to the body's complex immune response or blood clotting issues.

Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.

Blocking the virus's entry into cells by targeting certain pathways could lead to early COVID-19 treatments.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Applying a specific inhibitor lightens skin and hair color.

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

New treatments for Hepatitis C show promise but need more research to confirm their safety and effectiveness for clinical use.

Anti-androgens, like finasteride, dutasteride, and spironolactone, may lessen the severity of COVID-19 in men, leading to fewer ICU admissions.

Androgenetic alopecia linked to COVID-19 severity; drugs reducing androgen receptor activation may help.

Understanding the genetics of rare inherited ichthyosis syndromes is key for better treatments and genetic counseling.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

Low-potency steroids can cause serious side effects in people with skin conditions like Netherton syndrome.

Apple extract called procyanidin B-2 was found to greatly increase hair growth.

5-alpha-reductase inhibitors may reduce COVID-19 symptoms in bald males.

Spironolactone might help protect against severe lung problems in COVID-19 patients.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

AGA linked to worse COVID-19 outcomes in men.

Certain substances that block a specific protein help promote hair growth.

Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.

PDI helps restore over-bleached hair's strength and structure by attaching special peptides.

Activin activation in skin cells speeds up wound healing without affecting scar quality.

Having a lot of gray hair and hair loss are linked to more severe COVID-19.