Cyclosporine A Demonstrates Bilayer Modification With Slow Kinetics

    February 2018 in “ Biophysical Journal ”
    Hanan Baker, Thasin Peyear, Olaf S. Andersen
    TLDR Cyclosporine A slowly changes cell membranes, explaining some of its effects and side effects.
    The study investigated the effects of Cyclosporine A on lipid bilayers, revealing that it acts as a bilayer-modifying molecule with slow kinetics. This slow modification process may be linked to the conformational shifts required for Cyclosporine A to transition from a water-soluble to a hydrophobic state, facilitating its movement across biological membranes. These findings help explain some of the drug's effects and side effects, such as hair growth, which are not accounted for by its known mechanism of inhibiting calcineurin in T-cells.
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