Hidradenitis Suppurativa and Mediterranean Fever Gene Mutations

The document discussed the association between hidradenitis suppurativa (HS) and mutations in the Mediterranean fever gene (MEFV), highlighting that HS, an autoinflammatory disease, could present with severe phenotypes when associated with familial Mediterranean fever (FMF). It was noted that MEFV mutations were more frequent in patients with severe HS compared to the general population, suggesting a molecular link between FMF and HS-related syndromes like PASH and PAPASH. The study emphasized the importance of investigating serum amyloid A levels in HS patients as a predictor of amyloidosis and the need for further research into the immunogenetic background of HS, especially in regions with high FMF prevalence.