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Different halogens on progesterone derivatives can either block or mimic male hormone effects, depending on their type and amount.

D-004 may be a natural alternative to finasteride for treating enlarged prostate and male baldness.

Finasteride negatively affects fish reproduction and gonadal development.

PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.

Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.

COVID-19 might affect male fertility, but more research is needed to understand the full impact.

Androgens increase norepinephrine release, promoting smooth muscle growth in male sex organs, which may contribute to benign prostatic hypertrophy.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

RU 58841 may treat acne, hair loss, and excessive hair growth.

Finasteride doesn't affect bone density in male rats.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

Benign Prostatic Hyperplasia may be caused by changes in how the body processes male hormones.

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

Finasteride doesn't affect bone density in male rats.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Stopping finasteride can improve sperm count in infertile men.

Finasteride effectively treats hematospermia in 3 months without side effects.

5-alpha reductase inhibitors may have additional effects on cancer, mental health, heart health, and hormone levels beyond treating prostate enlargement.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

Finasteride temporarily lowers male rat fertility without affecting libido.

New compounds can block testosterone effects in rats and might help treat conditions like prostate cancer and acne.

The developed model can predict effective 5-alpha-reductase enzyme inhibitors.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Flutamide rarely causes liver toxicity in prostate cancer patients.