36 citations
,
January 2010 in “Human & experimental toxicology” This case report found that two women developed toxic selenium levels after consuming paradise nuts, resulting in symptoms like massive hair loss and nail discoloration.
35 citations
,
January 2001 in “Journal of Animal Science” This study found that dietary selenium levels above 5 ppm can lead to selenosis in pigs, with white-haired pigs showing alopecia sooner than dark-haired pigs.
35 citations
,
April 1956 in “Journal of the American Medical Association” This study found that using selenium sulfide shampoo for seborrheic dermatitis was associated with hair loss, which ceased after discontinuing the shampoo.
30 citations
,
September 2016 in “Aging Cell” This study found that selenium deficiency in mice accelerated age-related conditions and metabolic decline but unexpectedly promoted longevity, suggesting low selenium levels might separate healthspan and lifespan.
27 citations
,
June 2010 in “Journal of the American Academy of Dermatology” Excessive selenium in supplements can cause hair loss and nail issues.
23 citations
,
October 1995 in “PubMed” This case report identifies alopecia universalis in a worker as a result of occupational selenium intoxication.
23 citations
,
August 1989 in “American Journal of Veterinary Research” In this study, high selenium diets from different sources caused weight and hair loss in pigs, with additional hoof and coronary band problems particularly in those fed sodium selenate.
21 citations
,
June 1991 in “Journal of Inherited Metabolic Disease” This case report observed that a selenium-deficient diet in a child with propionic acidaemia led to macrocytosis and hair abnormalities, which improved with selenium supplementation.
20 citations
,
February 2013 in “Nutrition” This article reviews the role of prebiotics and the potential of green tea and selenium as alternatives due to their non-toxic nature, but it reports no new research findings.
20 citations
,
August 1960 in “PubMed” This study investigated the effects of selenium sulfide suspension on hair roots after noticing higher abnormal hair root proportions in individuals using the preparation.
18 citations
,
September 2011 in “Livestock science” This study found that maternal Nano-Se supplementation in cashmere goats improved antioxidant status and promoted secondary hair follicle development in fetuses at 110 days.
16 citations
,
May 2019 in “Hormone and Metabolic Research” This systematic review found insufficient evidence to support protective effects of selenium on polycystic ovary syndrome complications, despite some studies suggesting it may reduce insulin resistance and dyslipidemia.
16 citations
,
December 2005 in “Journal of Animal Physiology and Animal Nutrition” This study found that both low and high dietary selenium levels reduced hair growth in adult dogs, with optimal growth observed at mid-range selenium concentrations.
16 citations
,
January 1996 This review discusses selenium's role in human and animal health, its deficiency's link to diseases in China, and the need for precise geochemical control data; it reports no new findings.
15 citations
,
July 1984 in “Nutrition Research” Selenium increased in hair but not in blood after taking supplements.
15 citations
,
March 1997 in “International Journal of Dermatology” In this case report, the authors describe green hair discoloration in a patient attributed to the use of selenium sulfide.
13 citations
,
October 1960 in “Experimental Biology and Medicine” This study found that small amounts of subcutaneously injected Se75 were deposited and retained in the hair of dogs for up to 316 days.
12 citations
,
July 1964 in “Archives of Dermatology” This study found that neither a single application nor prolonged exposure to selenium sulfide had a significant effect on hair growth or rest phase percentages.
11 citations
,
January 2016 in “BMC veterinary research” This study found that urinary selenium to creatinine ratio and serum selenium concentrations quickly respond to changes in dietary selenium, making them useful biomarkers for assessing selenium status in dogs.
11 citations
,
January 1993 in “Journal of Veterinary Diagnostic Investigation” This study identified chronic selenosis in horses in western Iowa due to elevated selenium intake from locally produced alfalfa hay, leading to symptoms like alopecia and hoof deformities.
10 citations
,
April 2019 in “Environmental Science and Pollution Research” In this study, selenium-rich diets enhanced antioxidant activity in aged mice, suggesting potential biological benefits, although further trials are needed to fully understand long-term risks and benefits.
9 citations
,
September 1989 in “PubMed” This study observed that selenium levels were lower in Sudanese children with malnutrition compared to healthy German children, with a good correlation between selenium and glutathione peroxidase activity.
7 citations
,
March 2023 in “European Journal of Dermatology” Using Selenium Disulfide shampoo weekly helps prevent scalp dermatitis flare-ups.
6 citations
,
March 2011 in “Experimental Dermatology” This study found that an imbalance of selenium in a C57BL/6 mouse model led to hair loss with color change and was linked with changes in hair follicle apoptosis markers.
5 citations
,
July 2019 in “Nutrients” This study found that boys in Mexico City with selenium intake below the recommended dietary allowance had lower odds of progressing to advanced stages of pubertal development, while no association was observed in girls.
4 citations
,
January 1989 This study found that growth affects selenium deposition in hair, nails, and other tissues of adult and weanling rats, indicating dietary and physiological factors may influence selenium levels.
4 citations
,
January 2016 in “Dermatology online journal” This report describes a case of acquired yellow hair discoloration in a 77-year-old woman, potentially caused by applying selenium sulfide after bacitracin zinc to her scalp.
2 citations
,
October 1961 in “Experimental Biology and Medicine” This study found that rabbits fed a diet deficient in Vitamin E developed severe muscular dystrophy that was not fully prevented by adding selenium, Vitamin E supplements, or natural feedstuffs, indicating other nutritional deficiencies.
2 citations
,
February 1983 in “International Journal of Cosmetic Science” This study found that both hard and soft selenium disulphide-based detergents significantly increased triglyceride levels in human hair, suggesting enhanced sebum production with reduced lipolytic activity, but showed no significant differences between their effects.
1 citations
,
August 2023 in “Journal of cosmetic dermatology (Print)” This review discusses the potential link between selenium supplementation and symptoms of chronic selenium toxicity, such as hair loss and nail dystrophy, due to excess intake leading to disruptions in hair and nail protein structure.