TLDR Selenium deficiency caused symptoms in a child, which improved with selenium supplements.
A child with biotin-non-responsive propionic acidaemia on a restricted diet exhibited macrocytosis and unusual hair texture with hypopigmentation, linked to low plasma selenium levels (45.9 µg/L) and inadequate dietary selenium intake (4.7 µg/day). Selenium supplementation (50 µg/day) over 4 months normalized plasma selenium levels (97.7 µg/L), reduced MCV, and significantly improved hair growth, color, and length. Similar clinical improvements were observed during subsequent periods of selenium supplementation, indicating that these symptoms were due to selenium deficiency.
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