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    Glossary Sebum

    oily substance produced by sebaceous glands in skin

    Sebum is an oily substance produced by sebaceous glands in the skin. It helps to lubricate and waterproof the skin and hair, providing a protective barrier against external elements. Sebum is composed of triglycerides, wax esters, squalene, and free fatty acids, and its overproduction can contribute to conditions like acne.

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    1. Sebum Free Fatty Acids Enhance the Innate Immune Defense of Human Sebocytes by Upregulating β-Defensin-2 Expression Journal of Investigative Dermatology · 2009 · 195 citations
    2. Terbinafine levels in serum, stratum corneum, dermis-epidermis (without stratum corneum), hair, sebum and eccrine sweat. Acta dermato-venereologica · 1991 · 121 citations
    3. Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia Biochemical Journal · 2014 · 67 citations
    4. The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia Journal of The American Academy of Dermatology · 1999 · 65 citations
    5. Normal Fur Development and Sebum Production Depends on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands 2011 · 40 citations
    6. Inhibition of Rat 5<i>α</i>-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of<i>Quercus acutissima</i>Cortex Evidence-based Complementary and Alternative Medicine · 2015 · 37 citations
    7. MK-386, an Inhibitor of 5α-Reductase Type 1, Reduces Dihydrotestosterone Concentrations in Serum and Sebum without Affecting Dihydrotestosterone Concentrations in Semen<sup>1</sup> The Journal of Clinical Endocrinology & Metabolism · 1997 · 37 citations
    8. Investigation of drug partition property in artificial sebum International Journal of Pharmaceutics · 2007 · 33 citations
    9. Female pattern hair loss, sebum excretion and the end-organ response to androgens British Journal of Dermatology · 2005 · 31 citations
    10. Diffusion properties of model compounds in artificial sebum International journal of pharmaceutics · 2007 · 29 citations
    11. The effect of the antiandrogen IIα-hydroxyprogesterone on sebum production and cholesterol concentration of sebum British Journal of Dermatology · 1982 · 27 citations
    12. Expression of dermcidin in sebocytes supports a role for sebum in the constitutive innate defense of human skin Journal of Dermatological Science · 2015 · 25 citations
    13. Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice Experimental Dermatology · 2013 · 22 citations
    14. Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production Bioorganic & Medicinal Chemistry Letters · 2007 · 17 citations
    15. Regional difference in sebum production by androgen susceptibility in human facial skin Experimental Dermatology · 2013 · 14 citations
    16. (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production Bioorganic & Medicinal Chemistry Letters · 2007 · 14 citations
    17. HAIR LOSS FROM SEBUM Archives of Dermatology · 1953 · 13 citations
    18. Murine Vibrissae Cultured in Serum-Free Medium Reinitiate Anagen Journal of Investigative Dermatology · 2007 · 13 citations
    19. Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery Journal of Medicinal Chemistry · 2010 · 11 citations
    20. 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2009 · 11 citations
    21. Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2007 · 11 citations
    22. Changes in serum free testosterone, sleep patterns, and 5‐alpha‐reductase type I activity influence changes in sebum excretion in female subjects Skin research and technology · 2014 · 10 citations
    23. Serum 3α-androstanediol-glucuronide is decreased in nonhirsute women with acne vulgaris Fertility and Sterility · 1996 · 10 citations
    24. In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus racemosus Willd. Root as Anti-Sebum and Pore-Minimizing Active Ingredients Molecules · 2022 · 8 citations
    25. Inhibition of Insulin-Like Growth Factor-1–Induced Sebum Production by Bilobetin in Cultured Human Sebocytes Annals of Dermatology · 2019 · 8 citations
    26. Serum irisin: A prognostic marker for severe acne vulgaris Journal of Cosmetic Dermatology · 2018 · 8 citations
    27. How storage post sampling influences the stability of sebum when used for mass spectrometry metabolomics analysis? Scientific Reports · 2024 · 7 citations
    28. Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2009 · 7 citations
    29. Ozenoxacin suppresses sebum production by inhibiting mTORC1 activation in differentiated hamster sebocytes The Journal of Dermatology · 2024 · 6 citations
    30. Association between serum melatonin and skin aging in an urban population of Mongolia Journal of cosmetic dermatology · 2019 · 6 citations