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Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

Cathepsin L is essential for normal hair growth and development.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Mutant mice help researchers understand hair growth and related genetic factors.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

The conclusion is that certain scalp tissue changes are characteristic of lichen planopilaris, with mucinous perifollicular fibroplasia being a new feature for diagnosis.

Male hormones are important for hair and oil gland development and can cause conditions like excessive hair growth and acne.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Cyclosporin is effective for treating skin conditions in small animals, but requires careful dosing and monitoring for side effects.

Activating β-catenin in different skin stem cells causes various types of hair growth and skin tumors.

Excessive hair growth in women often has no known cause and is not linked to race or other hormonal symptoms.

The conclusion is that acne, alopecia, and hyperhidrosis are common skin issues with various treatments available, and accurate diagnosis is key for effective management.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

EGF and FGF help hair growth by affecting cell differentiation and fiber growth.

Recognizing specific features of African-American hair can help diagnose hair loss conditions.

Eating high glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

Finasteride may cause sexual side effects like erectile dysfunction, but they are reversible and affect less than 2% of men.

Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.

Cyclosporin effectively and safely treated skin diseases in three pets with no side effects.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

The model suggests that scalp tension could lead to hair loss, with factors like blood vessel hardening, enlarged oil glands, and poor microcirculation also playing a role. It also hints at a possible link between skull shape and baldness pattern.

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.