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Key genes linked to immune response are highly active in lupus-affected hair follicles.

Key genes linked to immune response are upregulated in hair follicles and skin tissues in chronic discoid lupus erythematosus.

Hair loss in men may be caused by inflammation triggered by hormones, and treatments reducing inflammation could potentially promote hair growth.

Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.

Inflammasome proteins can indicate the severity and treatment response of various diseases and injuries.

Men are more likely to have severe respiratory viral infections like COVID-19 due to hormonal and genetic differences, while women generally have stronger immune responses.

Gene therapy shows promise for healing chronic wounds but needs more research to overcome challenges.

Type I interferons play a key role in the development of various skin diseases.

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Future research should focus on making bioengineered skin that completely restores all skin functions.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

Dengue virus can infect human hair follicle cells and may cause hair loss.

Innate immunity genes in hair follicle stem cells might have new roles beyond traditional immune functions.

Some small molecule antivirals show promise against COVID-19, but more research is needed to understand and improve them.

Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.

Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.

Self-amplifying RNA could be a better option for protein replacement therapy with lower doses and lasting effects, but delivering it into cells is still challenging.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.

Key genes linked to hair growth and cancer were identified in hairless mice.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

A new mutation in the TMEM173 gene and a risk allele in IFIH1 cause a unique set of immune-related symptoms.

CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.

Different immune responses cause hair loss in scalp diseases, with unique patterns in scalp psoriasis possibly protecting against hair loss.

PRP therapy increases hair density for androgenetic alopecia.

Thyroid hormones are important for skin health and might help treat skin diseases, but more research is needed to understand their effects fully.