August 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study concluded that placebo effects observed in older alopecia minoxidil studies are likely due to subjective hair count assessments and study design, rather than true improvements in hair growth.
This study identified Activin A and its antagonist follistatin as crucial regulators of hair cell differentiation in mice, suggesting a local gradient of Activin A influences auditory sensory epithelium development.
March 2019 in “Dermatologic Surgery” This abstract describes the Dermatologic Surgery journal, which publishes peer-reviewed articles on cosmetic and reconstructive skin surgery, but reports no new clinical findings.
This study found that upper-bulge epidermal stem cells in mouse hair follicles are specialized for nerve interactions, crucial for forming tactile sensory units, and influence touch responses via EGFL6 and αv integrin pathways.
April 2018 in “Journal of Investigative Dermatology” This study observed that β-catenin overexpression in human squamous cell carcinoma cells led to increased CREB expression, which significantly enhanced clonogenic activity, suggesting CREB as a β-catenin-regulated factor promoting cancer characteristics.
This study found that IL-1α and IL-7 secreted from keratinocytes in a genetically engineered mouse model can stimulate the expansion of γδT-cells, aiding in the proliferation of epidermal stem cells for wound healing.
September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that while 450nm blue light can inhibit collagen and induce oxidative stress in dermal fibroblasts, 850nm near-infrared light may enhance metabolic activity without causing oxidative damage, suggesting potential for tailored light therapies in skin treatments.
This study found that type XVII collagen (COL17) regulates interfollicular epidermis proliferation in both neonatal and aged mice through Wnt signaling, suggesting its potential as a target for anti-aging skin strategies.
April 2017 in “Journal of Investigative Dermatology” In this study, CTCF was found to play essential roles in epidermal differentiation and skin barrier formation, simultaneously acting as a suppressor of epithelial inflammatory responses in mouse skin.
April 2017 in “Our Dermatology Online” This study explored how septuagenarians and octogenarians responded hedonically to natural cosmetics that were marketed as making them feel younger and more attractive, using a simple satisfaction questionnaire.
This study found that loss of the DNA methyltransferase Dnmt3a, but not Dnmt3b, increased carcinogen-induced squamous tumors in murine epidermis, with combined deletion leading to more aggressive and metastatic carcinomas.
March 2017 in “International Society of Hair Restoration Surgery” Higher doses of minoxidil may help women who don't respond to the standard treatment.
This study found that deleting the Mad2l1 gene in mice leads to rapid onset of acute lymphoblastic leukemia and liver cancer due to induced chromosomal instability.
In this study, Smad4 deletion in satellite cells hindered skeletal muscle regeneration in adult mice and did not enhance regeneration in aged mice, indicating Smad4's crucial role in muscle repair.
This review discusses the complex process of wound healing and emerging areas of interest in wound treatment, reporting no new clinical findings.
Defective protein folding due to a mutation is key in ANE syndrome.
This study found that super-enhancers play a crucial role in driving malignant progression in squamous cell carcinoma stem cells through a regulatory network involving ETS2 transcription factors, highlighting the potential link between high ETS2 levels and poor patient outcomes in head and neck cancers.
May 2015 in “Immunology Endocrine & Metabolic Agents - Medicinal Chemistry” This study suggests that vitamin D and calcium signaling are crucial for normal wound healing, with deficiencies in these pathways potentially delaying recovery due to diminished stem cell activity and response.
This research suggests that plucked hair follicles may serve as a reliable surrogate tissue for tumor biopsies in drug development, based on a mouse model linking hair and tumor pharmacodynamic responses.
January 2012 in “Else Kröner-Fresenius Symposia” This symposium reported that DNA damage accumulation in aging stem cells affects genome integrity, highlighting novel mechanisms like Bmi1's role in DNA repair and the involvement of BATF in lymphoid differentiation.
This study found that subcutaneous administration of Botulinum toxin type A significantly reduced histamine-induced itch intensity and neurogenic inflammation in human skin compared to saline.
July 2003 in “Current Prostate Reports” Combining different treatments may be needed to effectively manage chronic prostatitis.
July 2018 in “Journal of The American Academy of Dermatology” This article discusses current visualization methods for assessing hair restoration therapy responses, noting imprecision in triangulated measurements and patient dissatisfaction with visible tattoos.
This chapter examines how toxins such as inorganic arsenic, dioxin, and bacterial toxins can disrupt the balance of keratinocyte stem cell regeneration and differentiation, affecting skin barrier maintenance.
May 2015 in “Journal of The American Academy of Dermatology” Minoxidil response testing helps predict hair growth success.
34 citations
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August 2005 in “Veterinary Dermatology” This descriptive study reports that zinc deficiency in two dairy goats likely resulted from hereditary malabsorption, requiring life-long zinc supplementation to prevent skin lesions.
23 citations
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August 2001 in “PubMed” In this study, finasteride treatment in men with androgenetic alopecia reduced the expression of caspases in hair follicles to levels similar to those in men with normal scalps.
17 citations
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January 2024 in “Journal of Materials Chemistry B” This paper reviews the current state of magneto-responsive biocomposites in wound dressings, highlighting their potential benefits in wound healing, such as remote control and enhancing tissue reconstruction, while addressing the need for more comprehensive research in this field.
10 citations
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July 2000 in “PubMed” This case report suggests that increased dietary calcium from alfalfa may have contributed to zinc deficiency in two adult female goats by blocking zinc absorption.