Calcium And Vitamin D Signaling In The Epidermal Response To Wounding

May 2015 in “ Immunology Endocrine & Metabolic Agents - Medicinal Chemistry ”

Daniel D Bikle, Chia-Ling Tu, Yuko Oda

vitamin D calcium signaling vitamin D receptor VDR calcium sensing receptor CaSR hair follicle stem cells wound healing epidermal response innate immune response inflammatory response

TLDR Vitamin D and calcium are essential for effective wound healing.

The study explored the roles of vitamin D and calcium signaling in the epidermal response to wounding, highlighting their importance in the normal innate immune and inflammatory response necessary for wound healing. It was found that vitamin D receptor (VDR) is crucial for maintaining hair follicle stem cells, which aid in wound closure. Mice lacking the calcium sensing receptor (CaSR) or VDR, especially on a low calcium diet, exhibited delayed wound healing due to reduced stem cell activation and proliferation. This delay was linked to a decrease in stem cell numbers in hair follicles and interfollicular epidermis, suggesting that both VDR and calcium signaling are vital for effective wound repair.

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