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Patients with Alopecia areata have fewer specific immune cells that normally regulate the immune system, which may contribute to the condition.

Stromal stem cells may help heal wounds by becoming structural cells or affecting the immune system, but more research is needed to understand how.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Hairless HRS/J mice resist Bacillus anthracis skin infections due to high numbers of immune cells, not because they lack hair follicles.

Skin stem cells remember past inflammation, helping them respond better to future injuries and possibly aiding in treating skin issues.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Adult stem cells are important for tissue repair and have therapeutic potential, but more research is needed to fully use them.

Immune cells around hair follicles help control hair growth and could be targets for treating hair disorders.

Fetal skin has unique immune cells different from adult skin.

Androgenetic alopecia involves immune cell disruptions, especially increased CD4+ T cells around hair follicles.

An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.

Hair follicles help attract immune cells to the skin during stress.

Activating TLR9 helps heal wounds and regrow hair by using specific immune cells.

Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.

Epidermal stem cells could lead to new treatments for skin and hair disorders.

Stem cells regenerate tissues and their behavior varies by environment, suggesting the hematopoietic system model may need revision.

Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.

Certain immune cells worsen post-surgery gut paralysis by activating a specific immune response.

Memory T cells in the skin balance staying put and moving into the blood, clustering around hair follicles, and increasing in number after infection.

Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.

The document concludes that immune system abnormalities cause alopecia areata, but the exact process is still not completely understood.

Nerve growth factor helps improve healing time and scar quality in burn wounds.

Activin increases skin tumor formation, skin Tregs help hair growth, lymph-node removal doesn't improve melanoma survival, cells can revert to stem cells in wound healing, and skin bacteria produce peptides that may treat infections.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

Hair follicles are normally protected from the immune system, but when this protection fails, it can cause hair loss in alopecia areata.

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

The review suggests that other immune cells besides CD8+ T cells may contribute to alopecia areata and that targeting regulatory cell defects could improve treatment.

The protein interleukin-1 alpha helps regenerate hair follicles and increase stem cell growth in mice.

New treatments for hair loss from alopecia areata may include targeting immune cells, using stem cells, balancing gut bacteria, applying fatty acids, and using JAK inhibitors.