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The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

Hormones like estrogen, testosterone, progesterone, and prolactin play complex roles in female sexual function, with testosterone potentially improving sexual desire, arousal, and satisfaction. However, more research is needed to establish safe and effective hormone treatments for female sexual dysfunction.

Methotrexate is a key, cost-effective drug for skin conditions, but requires careful monitoring for side effects.

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

Women with PCOS have fewer activated T cells in their ovarian follicles, which might affect fertility.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.

Finasteride and spironolactone both reduce hirsutism, but finasteride lowers androgen levels more.

Alopecia in captive rhesus macaques is affected by season, sex, age, housing, and stress, with complex links between stress hormones and hair loss.

Early detection and treatment of PCOS in teenagers is important to manage symptoms and prevent severe issues.

Testosterone therapy can help improve sexual desire and function in postmenopausal women but may cause side effects and is not FDA-approved for this use.

People with polycystic ovary syndrome may have a higher risk of heart problems due to abnormal nervous system control of their heart and blood pressure.

Quercetin may help with PCOS symptoms, but more research is needed.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Menstrual disorders are common in adolescents and can be influenced by weight, activity, and health issues, requiring careful evaluation and more research for effective treatment.

Women with severe types of PCOS are more likely to have metabolic syndrome, and belly fat is a key predictor of this risk.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Young women with PCOS have a higher risk of high blood pressure and metabolic syndrome, but these risks may decrease after age 40.

Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.

Finasteride and dutasteride effectively treat hair loss in men and women, but may cause side effects like low libido and depression.

Intermittent low-dose finasteride works as well as daily use for treating excessive hair growth in women.

Oriental herbal medicine with moxibustion may improve pregnancy rates and other symptoms in PCOS, but more high-quality research is needed.

Dutasteride is safe and effective for treating hair loss, but may decrease libido.

Unwanted facial hair significantly impacts over 40% of women's psychological and social well-being, and various treatment options are available.