Endocrine Aspects of Female Sexual Dysfunction

    July 2004 in “ The Journal of Sexual Medicine ”
    Susan Ruth Davis, André T. Guay, Jan L. Shifren, Norman A. Mazer
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    TLDR Hormones like estrogen, testosterone, progesterone, and prolactin play complex roles in female sexual function, with testosterone potentially improving sexual desire, arousal, and satisfaction. However, more research is needed to establish safe and effective hormone treatments for female sexual dysfunction.
    The 2004 study "Endocrine Aspects of Female Sexual Dysfunction" investigated the role of hormones in female sexual function. It found that hormones such as estrogen, testosterone, progesterone, and prolactin have complex roles in this area. Sex steroid insufficiency was linked to urogenital atrophy and could negatively impact central sexual thought processes. While systemic estrogen/estrogen progestin therapy was found to alleviate climacteric symptoms, it did not specifically improve hypoactive sexual desire disorder (HSDD) in premenopausal or postmenopausal women. Exogenous testosterone was shown to improve sexual desire, arousal, and satisfaction in small randomized controlled trials. However, the study concluded that more research was needed to define safe and effective endocrine treatments for female sexual dysfunction. The paper also called for improved methods for measuring total and free testosterone in women, establishing normal ranges for various androgens in women, and studying the long-term safety of exogenous testosterone, particularly its effects on hair and skin.
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