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The FDA rejected a testosterone drug again due to safety concerns.

The document concludes that various medications and treatments can have significant, sometimes adverse, effects on health outcomes.

Women with PCOS should be screened for heart disease risk and manage their health to prevent it.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

Anorexia and bulimia lead to serious health problems and increased risk of death, requiring aggressive treatment.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Circadian rhythms are crucial for stem cell function and tissue repair, and understanding them may improve aging and regeneration treatments.

Women with PCOS who have low SHBG are more likely to have low good cholesterol and metabolic syndrome.

Dermatologists play a key role in treating skin symptoms of PCOS like dark patches, excess hair, acne, and hair loss.

Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.

Obese women with PCOS are more likely to have fatty liver disease.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.

Subcutaneous contraceptives can cause side effects like menstrual changes, headaches, weight gain, and pain at the implant site.

Inner city teens had high retention rates for the contraceptive implant, especially those with a history of abortion.

Using micro-needling, low-level laser therapy, and platelet-rich plasma together significantly improves hair growth in people with hair loss.

Adding amber particles to polyamide fibers makes them suitable for medical textiles like compression socks.

Pediatric dermatologists need to understand the unique skin health needs of LGBTQIA youth to provide better care.

Young women with PCOS and no other heart risk factors have normal heart function.

Testosterone therapy for transmasculine individuals is generally safe with medical supervision, improves mental health, and has mixed effects on physical health.

Anorexia Nervosa and Bulimia Nervosa are complex eating disorders with increasing incidence among young females, significant morbidity, and varying mortality rates, requiring more research for better treatment.

New medications are improving depression treatment, emphasizing accurate diagnosis and chronic care.

Minoxidil might help treat acne scars by reducing collagen buildup.

Targeted anticancer therapies can cause severe side effects similar to traditional chemotherapy, but with different types.

Gene therapy shows promise for healing chronic wounds but needs more research to overcome challenges.

A new method can quickly and accurately detect drugs in hair.

Vertical sleeve gastrectomy improved metabolism, behavior, and reproduction in obese rats with PCOS.

Pegvaliase effectively reduces blood phenylalanine levels in most PKU patients, but requires personalized plans and good communication to manage side effects.