TLDR Obese women with PCOS are more likely to have fatty liver disease.
The study investigated the relationship between polycystic ovary syndrome (PCOS) and markers of metabolic and cardiovascular disease risk in 90 obese women, with 45 diagnosed with PCOS and 45 serving as age-matched controls. The results indicated that women with PCOS had a significantly higher prevalence of non-alcoholic fatty liver disease (NAFLD) (73.3% vs. 46.7%, P < 0.01) and a higher free androgen index (FAI) (10.4% vs. 6.8%, P < 0.01). Additionally, there was a trend towards higher insulin levels and lower insulin sensitivity (as measured by QUICKI) and reduced flow-mediated dilation (FMD) of the brachial artery in the PCOS group, although these were not statistically significant. The study concluded that NAFLD is more common in obese women with PCOS, which is an important consideration for their healthcare, including the choice of contraceptives.
119 citations,
November 2009 in “Human Reproduction” Women with PCOS and higher androgen levels are more likely to have fatty liver disease.
44 citations,
May 2008 in “Fertility and Sterility” Insulin resistance might not be enough to worsen blood vessel function in young, nonobese women with polycystic ovary syndrome.
352 citations,
January 2006 in “The Journal of Clinical Endocrinology and Metabolism” Most women referred for excess male hormone symptoms had polycystic ovary syndrome (PCOS), with other conditions being less common.
4809 citations,
January 2004 in “Fertility and Sterility” The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.
4025 citations,
December 2003 in “Human Reproduction” The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.
249 citations,
November 2003 in “Clinical endocrinology” Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.
119 citations,
November 2009 in “Human Reproduction” Women with PCOS and higher androgen levels are more likely to have fatty liver disease.
28 citations,
November 2019 in “Frontiers in Endocrinology” Vegetarian Indian women with PCOS have higher inflammation levels than non-vegetarians.
9 citations,
February 2022 in “Genes” Women with PCOS have more Bifidobacterium in their gut compared to those without PCOS.
35 citations,
May 2015 in “Arquivos De Gastroenterologia” Women with PCOS are more likely to have fatty liver disease and worse metabolic health.
62 citations,
October 2019 in “Liver International” Women with PCOS have more severe liver disease.
