July 2025 in “Bioactive Materials” This review summarizes advancements in biomedical engineering for hair follicle regeneration, highlighting strategies like cell transplantation and tissue engineering to reconstruct hair follicles, and discusses both their technical limitations and potential future innovations in regenerative medicine.
September 2023 in “Molecular frontiers journal” This paper highlights the growing interest in exosomes for their therapeutic and diagnostic potential in cosmetic dermatology, noting their roles in skin rejuvenation, postprocedural care, and antiaging treatments.
June 2025 in “Problems of Cryobiology and Cryomedicine” In this study, the researchers found that tyndallization effectively sterilizes aqueous solutions of hyaluronic acid without diminishing their regenerative properties, and these properties remain intact even at low temperatures, supporting potential applications in cryobiology and cryomedicine.
17 citations
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October 2015 in “Medicine and Pharmacy Reports” This article reviews current research on animal models for hair regrowth treatments and reports no new findings; it highlights the need for studies comparing therapy efficiency and long-term safety.
July 2026 in “Periodontology 2000” This study reviewed exosome-mediated interventions for alopecia, finding that they enhance hair regeneration by stimulating key pathways and improving hair properties, with clinical studies showing increased hair density and patient satisfaction, though further trials are needed for widespread clinical use.
The researchers reported that a 4-aminopyridine-loaded gel promoted wound healing and hair follicle regeneration in burn models, suggesting it might be a promising alternative to existing burn treatments.
83 citations
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September 2021 in “Advanced functional materials” This study introduced a multifunctional DNA hydrogel dressing that may enhance wound healing by promoting tissue regeneration, nerve repair, and immune response in diabetic infectious wounds.
192 citations
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January 2018 in “Burns & Trauma” This review discusses the advancements in biologic skin substitutes for wound treatment and their potential in enhancing cutaneous regeneration but reports no new clinical results.
November 2023 in “Journal of cosmetic dermatology” This review article evaluates the effectiveness of autologous fat transplantation in regenerative medicine and rejuvenation, highlighting its biocompatibility and non-immunogenic properties as a facial filler, and notes the variable outcomes based on adipose tissue size.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This source reviews current research on using exosomes for treating alopecia and finds promising preclinical evidence, particularly with exosomes from dermal papilla and adipose-derived stem cells. However, it highlights significant gaps in clinical translation regarding safety, delivery, and mechanisms, suggesting more rigorous studies are needed.
44 citations
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March 2008 in “Journal of Experimental Botany” This study found that during bark regeneration after girdling, immature xylem cells can transdifferentiate into phloem cells, with exogenous indole acetic acid accelerating this process.
May 2026 in “Journal of Nanobiotechnology” This study found that using a palmitoylated peptide, Pal-MPAPO, delivered through hydrogel microneedles effectively promoted hair regrowth in mice with efficacy comparable to minoxidil, while requiring less frequent application.
This study found that a transcription factor called FoxA is specifically required for the regeneration of the planarian pharynx, suggesting its critical role in organ-specific regeneration.
433 citations
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December 2022 in “Materials Today Bio” This review discusses the use of extracellular vesicle-loaded hydrogels in tissue regeneration and reports no clinical results; the authors highlight their potential and suggest future research directions.
60 citations
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June 2019 in “Ageing Research Reviews” This review discusses the potential of adipose-derived tissue components like nanofat and stem cells for aesthetic rejuvenation, covering their use in hair growth, scar reduction, and more, without reporting new clinical results.
8 citations
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January 2023 in “RSC Advances” This article reviews advancements in carbon dots for tissue engineering and regenerative medicine, highlighting challenges and future directions without presenting new clinical findings.
August 2026 in “Pharmaceutics” In this study, radiofrequency microporation significantly improved topical minoxidil delivery and hair regrowth in a mouse model of androgenetic alopecia, with minimal systemic exposure compared to oral administration, suggesting it could be a promising needle-free option for topical therapy.
July 2025 in “Journal of medical & health sciences review.” This review highlights the potential of ultrasound-assisted gene therapy for tissue regeneration by improving gene delivery efficiency through techniques like microbubble-mediated sonoporation. The authors discuss its applications in musculoskeletal, cardiovascular, and neural regeneration, while addressing future challenges in optimizing this non-invasive approach for clinical applications.
October 2023 in “Sovremennye tehnologii v medicine” This research found that LSE transplantation positively affects wound healing by promoting granulation tissue growth and minimizing cosmetic defects in ischemic non-healing wounds during preclinical studies. Additionally, the proposed smoothing coefficient helps assess the degree of wound bed filling with developing tissue.
1 citations
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October 2025 in “Frontiers in Bioengineering and Biotechnology” This study developed a multifunctional bilayer dressing containing nanosilver and basic fibroblast growth factor, which improved wound healing by preventing bacterial penetration, promoting angiogenesis and hemostasis, and accelerating cell proliferation and migration, outperforming a control group by increasing healing rates by 47% in vivo.
8 citations
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May 2023 in “Gels” This review discusses the advantages and progress of chitosan hydrogels in vascular regeneration for tissue engineering scaffolds, highlighting modifications to enhance their application and exploring future prospects.
4 citations
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December 2017 in “International Journal of Biomedicine” In this study, the introduction of autofibroblasts into ischemic wounds was found to be slightly less favorable for regenerative histogenesis compared to a dermal equivalent with heterofibroblasts, with minor differences in epidermis thickness, collagen fiber area, and blood vessel area.
June 2026 in “Frontiers in Cell and Developmental Biology” This review discusses autologous fat grafting in various medical procedures, emphasizing the differing effects of stromal vascular fraction and expanded adipose-derived stem cells on fat retention, but reports no new clinical results.
February 2026 in “Molecular and Cellular Probes” This systematic review synthesizes evidence from the past 20 years to highlight the potential of exosome-based therapies from stem cells and plants in improving cutaneous repair, skin aging, and challenging dermatological conditions through mechanisms like immunomodulation and collagen remodeling.
4 citations
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January 2020 in “Frontiers in Physiology” This review discusses molecular signaling pathways and nutritional factors influencing feather growth and regeneration in poultry and offers no new results; the authors suggest these insights may guide strategies for producing superior plumage.
70 citations
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February 2021 in “International Journal of Molecular Sciences” This review provides an overview of current research on AD-MSCs, PRP, and biomaterials, highlighting their safety and efficacy in treating soft tissue defects and chronic wounds without major side effects.
4 citations
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January 2014 in “BioMed Research International” This special issue reviews advancements in engineering cell microenvironments for tissue engineering, highlighting various studies on interventions like silk fibroin and platelet-rich plasma, but presents no new empirical findings.
August 2024 in “Stem Cell Research & Therapy” This review discusses current and emerging therapies for androgenetic alopecia, emphasizing regenerative treatments and nanotechnology advancements, but it reports no new clinical results.
1 citations
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September 2024 in “Journal of Education Health and Sport” This review evaluates the clinical use of composite dermal-epidermal skin substitutes, with a focus on advancements such as the "BioMask" for facial skin trauma, highlighting the potential of 3D bioprinting and bioengineered skin in improving wound treatment and reconstruction.
August 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” In a diabetic rat model, this study found that a novel scaffold loaded with stem cell-conditioned medium primed by specific Chinese herbal compounds significantly reduced early inflammation and accelerated wound healing.