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    Research 31–60 of 1000+

    1. Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase Journal of Medicinal Chemistry · 1993 · 89 citations
    2. Critical Developmental Periods for Effects on Male Rat Genitalia Induced by Finasteride, a 5α-Reductase Inhibitor Toxicology and Applied Pharmacology · 1993 · 86 citations
    3. Three-Month Treatment With a Long-Acting Gonadotropin-Releasing Hormone Agonist of Patients With Benign Prostatic Hyperplasia: Effects on Tissue Androgen Concentration, 5<i>α</i>-Reductase Activity and Androgen Receptor Content* 1989 · 82 citations
    4. Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency The Journal of Clinical Endocrinology and Metabolism · 2008 · 81 citations
    5. Inhibition of skin 5α-reductase by oral contraceptive progestins<i>in vitro</i> Gynecological Endocrinology · 2000 · 78 citations
    6. Structure of human type II 5 alpha-reductase gene Endocrinology · 1992 · 76 citations
    7. The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression Korean Journal of Urology · 2014 · 75 citations
    8. Outcome of long-term treatment with the 5α-reductase inhibitor finasteride in idiopathic hirsutism: clinical and hormonal effects during a 1-year course of therapy and 1-year follow-up Fertility and Sterility · 1996 · 75 citations
    9. The Effect of 5α-Reductase Inhibition With Dutasteride and Finasteride on Bone Mineral Density, Serum Lipoproteins, Hemoglobin, Prostate Specific Antigen and Sexual Function in Healthy Young Men 2008 · 72 citations
    10. Clinical and endocrine effects of finasteride, a 5α-reductase inhibitor, in women with idiopathic hirsutism Fertility and Sterility · 1995 · 70 citations
    11. 5α-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment Journal of Ethnopharmacology · 2011 · 69 citations
    12. Sexual dysfunction in subjects treated with inhibitors of 5α-reductase for benign prostatic hyperplasia: a comprehensive review and meta-analysis International Journal of Andrology · 2017 · 66 citations
    13. The efficacy and safety of 5α-reductase inhibitors in androgenetic alopecia: a network meta-analysis and benefit–risk assessment of finasteride and dutasteride Journal of Dermatological Treatment · 2013 · 66 citations
    14. Expression of mRNA for androgen receptor, 5alpha-reductase and 17beta-hydroxysteroid dehydrogenase in human dermal papilla cells 1999 · 63 citations
    15. 5alpha-reductase: history and clinical importance. PubMed · 2004 · 62 citations
    16. Studies on Neurosteroids XXV. Influence of a 5.ALPHA.-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008 · 61 citations
    17. A model for the turnover of dihydrotestosterone in the presence of the irreversible 5α-reductase inhibitors GI198745 and finasteride Clinical Pharmacology & Therapeutics · 1998 · 60 citations
    18. Discovery and Clinical Development of Dutasteride, a Potent Dual 5&#945;- Reductase Inhibitor Current topics in medicinal chemistry · 2006 · 58 citations
    19. Effect of 5α-Reductase Inhibitors on Sexual Function: A Meta-Analysis and Systematic Review of Randomized Controlled Trials The Journal of Sexual Medicine · 2016 · 57 citations
    20. 5α-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia International Journal of Cancer · 2006 · 57 citations
    21. Dihydrotestosterone Stimulates 5a-Reductase Activity in Pubic Skin Fibroblasts* 1983 · 57 citations
    22. Human Osteoblast-Like Cells Express Predominantly Steroid 5α-Reductase Type 1 The Journal of Clinical Endocrinology & Metabolism · 2002 · 56 citations
    23. Effects of the 5α-Reductase Inhibitor Finasteride on Serum Levels of Gonadal, Adrenal, and Hypophyseal Hormones and its Clinical Significance: A Prospective Clinical Study Steroids · 1998 · 56 citations
    24. C<sub>19</sub>and C<sub>21</sub>5<i>β</i>/5<i>α</i>Metabolite Ratios in Subjects Treated with the 5<i>α</i>-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5<i>α</i>-Reductase Deficiency* The Journal of Clinical Endocrinology and Metabolism · 1990 · 55 citations
    25. Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases International journal of risk & safety in medicine · 2018 · 54 citations
    26. 5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes Endocrinology · 2015 · 54 citations
    27. Inhibition of 5α-reductase in the nucleus accumbens counters sensorimotor gating deficits induced by dopaminergic activation Psychoneuroendocrinology · 2011 · 53 citations
    28. Nipple Differentiation in Fetal Male Rats Treated with an Inhibitor of the Enzyme 5<i>α</i>-Reductase: Definition of a Selective Role for Dihydrotestosterone* Endocrinology · 1986 · 53 citations
    29. Inhibitors of 5&#945;-Reductase in the Treatment of Benign Prostatic Hyperplasia Current pharmaceutical design · 2006 · 52 citations
    30. Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 51 citations