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    Did you mean 5α-reductase?
    Glossary 5α-reductase

    enzyme converting testosterone into potent dihydrotestosterone (DHT)

    5α-reductase is an enzyme that converts testosterone into dihydrotestosterone (DHT), a more potent androgen hormone. This enzyme plays a significant role in various biological processes, including the development of male characteristics and the regulation of hair growth. Inhibitors of 5α-reductase, such as finasteride, are commonly used to treat conditions like male pattern baldness and benign prostatic hyperplasia.

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    1. Influence of Oxidative and/or Reductive Treatment on Human Hair (I): Analysis of Hair-Damage after Oxidative and/or Reductive Treatment Journal of oleo science · 2003 · 20 citations
    2. Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts Molecular & cellular proteomics · 2019 · 9 citations
    3. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997 · 416 citations
    4. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor 2004 · 408 citations
    5. 5α-reductase activity in the prostate Urology · 2001 · 237 citations
    6. DIHYDROTESTOSTERONE AND THE PROSTATE: THE SCIENTIFIC RATIONALE FOR 5α-REDUCTASE INHIBITORS IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA 2004 · 235 citations
    7. Adverse Side Effects of 5α‐Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010 · 223 citations
    8. An overview on 5α-reductase inhibitors Steroids · 2009 · 219 citations
    9. The importance of dual 5α-reductase inhibition in the treatment of male pattern hair loss: Results of a randomized placebo-controlled study of dutasteride versus finasteride Journal of The American Academy of Dermatology · 2006 · 215 citations
    10. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007 · 195 citations
    11. Species Differences in Prostatic Steroid 5<i>α</i>-Reductases of Rat, Dog, and Human Endocrinology · 1985 · 193 citations
    12. Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes Molecules · 2011 · 186 citations
    13. Dihydrotestosterone and the Concept of 5&alpha;&ndash;Reductase Inhibition in Human Benign Prostatic Hyperplasia European Urology · 2000 · 184 citations
    14. Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes Journal of Investigative Dermatology · 1998 · 169 citations
    15. The Risks and Benefits of 5α-Reductase Inhibitors for Prostate-Cancer Prevention 2011 · 147 citations
    16. Effects of Finasteride (MK-906), a 5<i>α</i>-Reductase Inhibitor, on Circulating Androgens in Male Volunteers* The Journal of Clinical Endocrinology and Metabolism · 1990 · 147 citations
    17. Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production JAMA · 2012 · 124 citations
    18. Comparison of finasteride (proscar®), a 5α reductase inhibitor, and various commercial plant extracts in in vitro and in vivo 5α reductase inhibition The Prostate · 1993 · 124 citations
    19. Structure of human type II 5 alpha-reductase gene. Endocrinology · 1992 · 124 citations
    20. External genitalia abnormalities in male rats exposed in utero to finasteride, a 5α-reductase inhibitor Teratology · 1990 · 122 citations
    21. Steroid 5α-reductases and 3α-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism 2001 · 115 citations
    22. Adverse effects of 5α-reductase inhibitors: What do we know, don’t know, and need to know? Reviews in Endocrine and Metabolic Disorders · 2015 · 111 citations
    23. 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder Neuropsychopharmacology · 2015 · 110 citations
    24. The Rationale for Inhibiting 5α-Reductase Isoenzymes in the Prevention and Treatment of Prostate Cancer 2008 · 108 citations
    25. 9 Role of 5α-reductase in health and disease Baillière's clinical endocrinology and metabolism · 1994 · 101 citations
    26. Immunohistochemical localization of types 1 and 2 5α-reductase in human scalp British Journal of Dermatology · 1999 · 100 citations
    27. Inhibition of rat α-reductases by finasteride: Evidence for isozyme differences in the mechanism of inhibition The Journal of Steroid Biochemistry and Molecular Biology · 1997 · 98 citations
    28. 5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents Diabetes · 2014 · 93 citations
    29. 5α‐Reductase Isozymes and Androgen Actions in the Prostate Annals of the New York Academy of Sciences · 2009 · 93 citations
    30. Association of Suicidality and Depression With 5α-Reductase Inhibitors JAMA Internal Medicine · 2017 · 90 citations