6 citations,
November 2021 in “Oncology Research and Treatment” Low Vitamin D receptor levels in breast cancer are linked to worse outcomes and more bone metastases, and could be a marker for prognosis.
6 citations,
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6 citations,
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![Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia](/images/research/9620bd26-3366-4f2a-bcac-f511697bbc41/small/35997.jpg)
6 citations,
January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin” A new compound shows promise as a topical treatment for hair loss.
5 citations,
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February 2023 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” The study found that certain mutations in the vitamin D receptor can cause rickets and potentially affect hair growth.
4 citations,
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4 citations,
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4 citations,
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3 citations,
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3 citations,
July 2019 in “Journal of Cosmetic Dermatology” New shampoo with tyramine hydrochloride reduces hair loss by making a small muscle in the hair follicle contract.
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August 2013 in “Journal of the American Academy of Dermatology” A new method quickly detects hair changes from EGFR inhibitors using a microscope.
2 citations,
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2 citations,
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1 citations,
February 2022 in “Clinical, Cosmetic and Investigational Dermatology” TDM10842, a thyroid hormone receptor activator, was found to effectively promote hair growth in mice.
1 citations,
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This study highlights the crucial role of ligand-independent actions of the vitamin D receptor (VDR) in maintaining hair cycle and skin homeostasis. In VDR-KO rats, which lack the VDR gene, there is significant alopecia and skin abnormalities, including hyperkeratosis and increased trans-epidermal water loss. In contrast, rats with a mutant VDR (R270L/H301Q) that cannot bind ligands do not exhibit these issues, indicating that VDR's non-liganded actions are essential. The study found that VDR-KO rats have altered gene and protein expression, particularly in the Shh, Wnt, and Bmp signaling pathways, with decreased hair keratins and increased epidermal keratins. These findings underscore the importance of non-liganded VDR in keratinocyte differentiation, proliferation, and cell death in hair follicles and the epidermis.