Expression of CD117 and Platelet-Derived Growth Factor Receptor α in Patients with Alopecia Areata

    Saritha Mohanan, Mary Theresa Sylvia, Carounanidy Udayashankar, Ramachandran V Bhat
    Studysummary This study found that the expression of CD117 and platelet-derived growth factor receptor α differs in alopecia areata tissue compared to normal controls, with platelet-derived growth factor receptor α correlating with disease severity.
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    Research cited in this study 11

    1. Emerging Unconventional Therapies for Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2017
    2. Platelet-Derived Growth Factor Signaling Modulates Adult Hair Follicle Dermal Stem Cell Maintenance and Self-Renewal npj Regenerative Medicine · 2017
    3. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    4. A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata British Journal of Dermatology · 2013
    5. Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations Acta Histochemica Et Cytochemica · 2010
    6. PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles Journal of Dermatological Science · 2006
    7. Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts Journal of Investigative Dermatology · 2004
    8. Autoimmunity: Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2004
    9. Regulation of PDGF and PDGF Receptor in Cultured Dermal Papilla Cells and Follicular Keratinocytes of the Human Hair Follicle Experimental Dermatology · 2003
    10. Alopecia Areata: Animal Models Clinical and Experimental Dermatology · 2002
    11. Growth Factor and Growth Factor Receptor Localization in the Hair Follicle Bulge and Associated Tissue in Human Fetus Journal of Investigative Dermatology · 1996