Expression of CD117 and Platelet-Derived Growth Factor Receptor α in Patients with Alopecia Areata

January 2020 in “ Indian journal of dermatology, venereology, and leprology ”

Saritha Mohanan, Mary Theresa Sylvia, Carounanidy Udayashankar, Ramachandran V Bhat

CD117 platelet-derived growth factor receptor α alopecia areata anagen hairs catagen hairs platelet-rich plasma immunohistochemistry PRP

From the encyclopedia

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Platelet-Rich Plasma →

growth factors taken from your blood and injected into your scalp to stimulate hair

Studysummary This study found that the expression of CD117 and platelet-derived growth factor receptor α differs in alopecia areata tissue compared to normal controls, with platelet-derived growth factor receptor α correlating with disease severity.

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The study compared CD117 and PDGFRA expression in 30 alopecia areata patients and 18 controls, finding significantly higher CD117 expression in alopecia areata patients' hair follicles. PDGFRA expression was not significantly different but correlated with alopecia severity. The results suggested roles for CD117 and PDGFRA in alopecia areata pathogenesis, with CD117 showing a more pronounced difference. However, the expression patterns could not be confirmed by western blot or real-time PCR, indicating a need for further research.

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11 / 11 results

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