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Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

Five new mutations in the androgen receptor gene were found, helping to understand androgen insensitivity syndrome better.

ZD1839 (Iressa) causes skin and hair side effects, treatable with tretinoin cream and minocycline.

Estrogen affects hair growth and skin cell multiplication.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Higher androgen levels and site-specific AR expression cause sex-related skeletal differences, and certain steroids can boost AR expression and androgen effects in bone cells.

Activating TRPV3 stops human hair growth.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Prolactin affects hair growth cycles and can cause early hair follicle regression.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

A certain smell receptor in hair follicles can affect hair growth when activated by a synthetic sandalwood scent.

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

High-dose androgen therapy can help manage certain types of androgen resistance.

The three estrogen receptor genes are highly expressed in zebrafish neuromasts during development.

E211 G>A gene linked to lower risk of severe prostate cancer and hair loss.

Prolactin affects when mice shed and grow hair.

A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.

Genetic differences may affect COVID-19 deaths; anti-androgens could be potential treatment.

Estradiol stops hair growth in mice, but an antagonist can reverse this effect.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Prostaglandin D2 blocks new hair growth after skin injury through the Gpr44 receptor.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.