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Hormones during puberty increase certain receptors in the brain, and this change is influenced by estrogen levels.

Mutations in the RBPJ gene cause Adams-Oliver Syndrome.

Finasteride may affect male fertility by interfering with specific sperm signaling.

Ephrin-A3 helps increase and speed up hair growth in baby mice.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

Key genes can rewire networks, changing skin appendage types.

The conclusion is that certain genetic factors and blood types may affect COVID-19 severity, but changes in ACE2 and TMPRSS2 genes are not clearly linked to it.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

Finding functions for unknown GPCRs is hard but key for making new drugs.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Androgens can both promote and prevent hair growth due to differences in gene expression in hair follicles.

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.

Researchers found new genes involved in hair growth, which could help develop new hair treatments.

Early diagnosis and treatment of PCOS is crucial to reduce emotional distress and health risks.

The document concludes that computational models are useful for understanding immune responses and could improve cancer immunotherapy.

Saw palmetto supplements may reduce prostate cancer cell growth without being toxic.

Finasteride blocks progesterone production in specific tumor cells, potentially causing side effects.