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Hair gets thinner, grayer, and changes texture with age due to genetics, environment, and cellular changes, affecting the growth cycle.

Radiation mainly affects keratinocyte stem cells, not melanocyte stem cells, causing hair to gray.

The document concludes that stem cell inactivity is actively controlled and important for tissue repair and balance.

Spironolactone nano-formulations show promise for treating skin disorders, but more research is needed for safety and effectiveness.

Runx genes are important for stem cell regulation and their roles in aging and disease need more research.

Nuclear Factor I-C is important for controlling hair growth by affecting the TGF-β1 pathway.

mTORC1 signaling needed for quick hair follicle recovery after radiation damage.

Immune checkpoint inhibitors can cause skin issues but are linked to better cancer outcomes.

Sex and sex hormones can affect brain inflammation in Parkinson's disease, with male mice being more affected and female mice showing a protective effect.

There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.

Melanogenesis inhibitors like kojic acid and niacinamide can reduce inflammation and pigment production in skin cells.

A young Saudi girl with uncontrolled type 1 diabetes and hypothyroidism had two rare conditions, Mauriac syndrome and Van Wyk–Grumbach syndrome.

Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.

A 19-year-old male with delayed puberty was successfully treated for a condition that prevents normal hormone production.

Older skin has higher cancer risk due to inflammation and stem cell issues.

Graying hair happens due to aging and might be delayed by new treatments.

Systemic corticosteroids can help treat rapidly spreading vitiligo but require more research for safer use.

EGFR helps mouse hair follicles stop growing by reducing certain growth regulators.

Vitamin D helps protect skin, PSORS1 gene's risk interval for psoriasis is expanded, hair follicles can be generated from mouse cells, and interferon-γ may cause pigmented skin lesions.

Notch1 signaling is crucial for improving wound healing and skin regeneration by affecting stem cell behavior.

Skinny fat cells help wounds heal faster by releasing fatty acids.

The document explains the difficulty in diagnosing and treating brain diseases caused by the immune system and stresses the need for quick and accurate tests.

Hair loss reduces hair thickness and coverage, but drug treatments mainly revive dormant hairs rather than reverse thinning; patients often undervalue their hair loss severity.

COVID-19 and vaccines cause various skin reactions and highlight the need for dermatologists in managing these issues and addressing vaccine distribution disparities.

Type 1 Diabetes prevents hair growth by causing cell death in hair follicles.

Stress in mice delays hair growth and treatments blocking substance P can partly reverse this effect.

Wigs help improve self-esteem and quality of life for people with hair loss from alopecia areata.

JAM-A helps hair regrowth in alopecia areata by protecting VCAN in skin cells.

Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.

The gene p53 is crucial for removing damaged cells to allow for healthy tissue renewal.