Clinical Snippets: Dermatological Studies on hCAP18, PSORS1, Hair Follicle Generation, and Solar Lentigines
April 2005
in “
Journal of Investigative Dermatology
”
TLDR Vitamin D helps protect skin, PSORS1 gene's risk interval for psoriasis is expanded, hair follicles can be generated from mouse cells, and interferon-γ may cause pigmented skin lesions.
The document discussed several dermatological studies. Weber and colleagues found that the antimicrobial protein hCAP18 was upregulated in the skin after applying a vitamin D analog, suggesting vitamin D's role in skin protection. Elder's team studied the PSORS1 gene in psoriasis and found that cluster 17 does not carry a psoriasis-susceptibility allele, expanding the risk interval for PSORS1. Zheng's group developed a "hair patch" assay to generate hair follicles from mouse cells, providing a model for studying new organ formation. Aoki and Moro's research on solar lentigines in mice indicated that interferon-γ might be crucial in developing these pigmented lesions.
