April 2005 in “Journal of Investigative Dermatology” Vitamin D helps protect skin, PSORS1 gene's risk interval for psoriasis is expanded, hair follicles can be generated from mouse cells, and interferon-γ may cause pigmented skin lesions.
19 citations,
July 2020 in “EBioMedicine” A gene variant increases the risk of a type of hair loss by affecting hair protein production.
December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Stress can cause a type of hair loss in mice lacking the CCHCR1 gene.
37 citations,
June 2004 in “Human molecular genetics online/Human molecular genetics” The HCR gene contributes to psoriasis risk.
Psoriasis is a genetically influenced, immune-mediated inflammatory skin disease affecting over 60 million people globally, with chronic plaque psoriasis being the most common form. Genetic loci like PSORS1 and CARD14 are significant, and environmental factors such as infections, stress, and lifestyle choices impact disease onset and severity. Stress-reducing interventions can enhance treatment efficacy. The Koebner phenomenon and the roles of innate and adaptive immunity are crucial in its pathogenesis. Psoriasis plaques involve a complex inflammatory network, and targeted biologic treatments show promise. While scalp psoriasis typically does not cause hair loss, severe forms like erythrodermic psoriasis can. The disease can present in infancy and affect genital skin in inverse psoriasis.