32 citations
,
May 2017 in “Lasers in medical science” This study found that radiofrequency treatment, with or without hydrolyzed collagen, increased dermis thickness, neocollagenesis, and FGF2 overexpression in rat skin tissue.
27 citations
,
August 2014 in “Journal of Cosmetic and Laser Therapy” This study compared the microscopic treatment zones created by different fractional lasers and radiofrequency in swine skin, finding distinct patterns and damage levels for each technology.
48 citations
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May 2012 in “Journal of cosmetic and laser therapy” This study found that fractional bipolar RF energy significantly reduced acne scar severity and improved skin texture, with high subject satisfaction and limited side effects.
4 citations
,
June 2024 in “Journal of Cosmetic Dermatology” In this study, fractional radiofrequency treatment was found to be effective, safe, and well-tolerated for patients with erythematotelangiectatic rosacea, with high satisfaction rates.
4 citations
,
November 2023 in “Journal of Cosmetic Dermatology” In this study, researchers found that negative pressure fractional microneedle radiofrequency significantly improved periorbital wrinkles, hydration, and dermal thickness in patients with periorbital aging, while also increasing orderly collagen and elastic fibers, with minimal adverse effects reported.
1 citations
,
April 2026 in “Aesthetic Plastic Surgery” This study found that radiofrequency microneedling is effective and well-tolerated for improving various skin conditions, showing comparable efficacy to fractional lasers for atrophic acne scars with generally favorable patient satisfaction and safety.
51 citations
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September 2013 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study found that fractional radiofrequency microneedle treatment was safe and effective for improving acne scars in Asians, with minimal adverse effects reported at 6-month follow-up.
February 2021 in “Dermatological reviews” In this study, a specially adapted nonablative radiofrequency device significantly increased hair growth measures in most patients with androgenetic alopecia, including hair count and density.
3 citations
,
July 2025 in “Journal of Cosmetic Dermatology” In this study, both Endo-RF subcision and the combination of Endo-RF subcision with PRP were shown to be safe and effective for improving post-acne scars, with the combination therapy potentially offering more desirable outcomes.
September 2025 in “Tạp chí Da liễu học Việt Nam” In this study, combining ablative fractional microneedle radiofrequency with oral methylprednisolone was found to enhance hair density and mature hair rates in patients with alopecia areata better than oral methylprednisolone alone, though some adverse effects and increased hair shedding were noted over time.
42 citations
,
December 2014 in “Clinical, cosmetic and investigational dermatology” This review indicates that microneedle bipolar RF and fractional bipolar RF treatments offer significant improvement in acne scarring, with optimal results observed about three months after treatment.
January 2019 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)” This study found that the treatment group experienced a higher average increase in hair counts than the placebo group, but the difference was not statistically significant.
March 2025 in “Dermatologic Surgery” This study found that fractional radiofrequency microneedling may be as effective and safe as intralesional corticosteroid injections for treating patchy alopecia areata, with potentially fewer side effects.
July 2023 in “Journal of Education, Health and Sport” This literature review reports that micro-needle radiofrequency is increasingly recognized in aesthetic medicine as a safe, effective treatment for various skin conditions, but further research is needed to optimize treatment parameters for the best outcomes.
26 citations
,
November 2012 in “Clinics in Plastic Surgery” This article reviews treatments focused on stimulating collagen synthesis and improving skin appearance through methods like mechanical dermabrasion and laser surgery, but it reports no new clinical results.
3 citations
,
December 2014 in “Aesthetic dermatology” This book reviews the evolving use of radiofrequency in aesthetic medicine and its comparison with laser and surgical approaches, but it reports no new clinical results.
June 2021 in “Dermatologic surgery” This review discusses the measurement of patient satisfaction in acne scar treatment studies, highlighting the need for standardized satisfaction questions to enhance comparability and future research; it reports no new clinical results.
115 citations
,
April 2010 in “Archives of Dermatology” In this randomized, blinded study, the surgical face-lift improved facial skin laxity by 49% compared to 16% with a minimally invasive fractional radiofrequency treatment, with FRF causing fewer adverse effects.
September 2017 in “Journal of aesthetic nursing” This review discusses several popular treatments for reducing facial wrinkles, including botulinum toxin, dermal fillers, radiofrequency, and ultrasound, and reports no new clinical results.
December 2024 in “Фарматека” Oral collagen combined with other treatments effectively reduces hair loss and improves hair quality in telogen effluvium.
January 2023 in “International journal of dermatology, venereology and leprosy sciences” This study suggests that microneedling may be an effective and less painful treatment for vitiligo, offering benefits over traditional needle injections, particularly in challenging-to-treat areas like the extremities or stubborn regions.
February 2024 in “Lasers in Medical Science” This review discusses laser and energy-assisted drug delivery as a treatment for alopecia and concludes that although all studies show positive effects, some reports indicate no superiority over existing monotherapies.
13 citations
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May 2025 in “Journal of Cosmetic Dermatology” This study reports that adipose mesenchymal stem cell-derived exosomes and platelet-rich plasma both improved the condition of photoaged facial skin, with no significant difference in effectiveness between the two treatments, potentially offering a quicker and less invasive option for patients.
2 citations
,
January 2015 in “Case reports in neurological medicine” In this case report, pulsed radiofrequency neuromodulation provided over 80% pain relief for five months in a patient with chronic lesser occipital nerve pain after other treatments failed.
November 2025 in “Medical alphabet” This study highlights that physiotherapeutic methods like low-intensity laser therapy, radiofrequency, and electrical stimulation show promising effectiveness in stimulating hair growth and treating telogen effluvium by enhancing cell activity, ATP synthesis, and transdermal drug delivery.
July 2024 in “International Journal of Molecular Sciences” In this ex vivo and in vitro study, researchers found that capacitive resistive electrical transfer therapy increased cell proliferation and reduced cell death in hair follicles from patients with androgenic alopecia, suggesting potential benefits for alopecia treatment.
1 citations
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January 2023 in “The Egyptian Journal of Hospital Medicine” This study found that combining platelet-rich plasma with microneedling and subcision was effective in treating atrophic acne scars in over 80% of patients with minimal adverse effects.
11 citations
,
January 2013 in “Ocular Surface” This review summarizes the ophthalmic complications of common periocular aesthetic treatments but reports no new clinical findings, emphasizing the importance of recognizing potential side effects.
December 2025 in “Pakistan Journal of Health Sciences” This systematic review found that estrogen deficiency in postmenopausal women leads to structural and symptomatic changes in genital and cutaneous tissues, with local estrogen therapy providing short-term benefits, while evidence for device-based treatments remains limited and requires larger trials.
January 2015 in “Aesthetic Surgery Journal” This article reviews cosmetic dermatology as presented in the January 2014 volume of Dermatologic Clinics and reports no new clinical findings.