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The environment around the time of conception can change the VTRNA2-1 gene in a way that lasts for years and may affect disease risk.

Acitretin is effective for severe skin conditions but has significant side effects and requires careful monitoring.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

Insulin resistance is linked to high male hormone levels in women, often seen in those with PCOS.

The research suggests that the ZP4 gene is linked to egg development in women with PCOS but requires more study to understand its role in infertility.

High doses of rosemary extract can harm the liver, kidneys, and reproductive organs in young rats.

Cinnamon can help manage symptoms of polycystic ovary syndrome, improve menstrual cycles and fertility, and positively affect cholesterol and blood sugar levels, but more research is needed to confirm these effects and find the best dosage.

Low-Level Light Therapy (LLLT) is a safe and effective method for skin rejuvenation, acne treatment, wound healing, body contouring, and hair growth, but more well-designed trials are needed for confirmation.

Higher hair calcium to magnesium ratios and lower chromium levels in hair may indicate insulin resistance in Korean men.

Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.

Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.

CRISPR/Cas9 has improved precision and control but still faces clinical challenges.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

Tadalafil and Finasteride may help treat aggressive melanoma.

Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.

A new small peptide may help hair growth by activating a specific receptor and should be tested in humans.

The document concludes that more research is needed to understand hair loss in men and to find new treatments.

Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.

Keratin 18 helps diagnose and predict cancer progression and affects cancer growth and spread.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Spermidine may help reduce hair loss and deserves further testing as a treatment.

Systemic diseases can cause hair loss, which is often reversible with treatment.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

A new gene mutation causes insulin resistance in a girl and her mother.

The research suggests that autophagy-related genes might play a role in causing alopecia areata.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

Blocking JAK3 signaling can reverse hair loss from alopecia areata.

ILK is essential for skin development, pigmentation, and healing.